Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at support@zacks.com or call 800-767-3771 ext.  9339.

Synergy Pharmaceuticals Inc. (SGYP - Snapshot Report) recently announced that the enrolment procedure of its phase IIb study on plecanatide has reached the halfway mark. Plecanatide is being developed for the treatment of patients suffering from irritable bowel syndrome with constipation (IBS-C).

Synergy Pharma expects to enrol a total of 350 patients suffering from IBS-C for the phase IIb study, which is being conducted around 70 sites in the US. Synergy Pharma expects to enrol the last patient for the study in the final quarter of 2013. Synergy Pharma expects to release top-line data from this study in the first quarter of 2014.

We remind investors that Synergy Pharma is also developing plecanatide for the treatment of patients suffering from chronic idiopathic constipation (CIC). In May this year, the company reported positive results from a multicenter trial on plecanatide for the CIC indication. Synergy Pharma observed statistically significant improvement in the number of complete spontaneous bowel movements among patients, who were administered three doses of plecanatide.

The study also showed that patients experienced improvements in other symptoms of chronic constipation as well, including decreased stool hardness and straining. An improvement in the quality of life was observed in CIC patients treated with plecanatide.

Synergy Pharma intends to pursue the development of plecanatide for the treatment of CIC with pivotal trials expected to begin before Dec 31, 2013.

We expect investor focus to remain on updates regarding the future development of plecanatide. The successful development and commercialization of plecanatide would be a major positive for Synergy Pharma, which currently has no approved drug.

The constipation market already has Linzess for treating adults suffering from IBS-C or CIC.

Synergy Pharma, a biopharmaceutical company, currently carries a Zacks Rank #3 (Hold). Biopharma companies like Jazz Pharmaceuticals Public Limited Company (JAZZ - Analyst Report), Sarepta Therapeutics, Inc. (SRPT - Snapshot Report) and Medivation, Inc. (MDVN - Analyst Report) currently appear to be more attractive. While Jazz Pharma and Sarepta carry a Zacks Rank #1(Strong Buy), Medivation carries a Zacks Rank #2(Buy).

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
GENERAL FINA GFN 8.20 +5.67%
QIHOO 360 TE QIHU 91.57 +4.38%
VIPSHOP HOLD VIPS 140.01 +3.49%
INVESTMENT T ITG 19.16 +3.34%
VERTEX ENERG VTNR 7.38 +3.07%