Back to top

Analyst Blog

Merrimack Pharmaceuticals, Inc. (MACK - Snapshot Report) recently advanced its oncology candidate MM-111 to a phase II development. The company started enrolling patients in the phase II study of MM-111. MM-111 is a bispecific antibody being developed for the treatment of advanced gastric, esophageal and gastroesophageal junction (GEJ) cancers.

The study will evaluate the safety and efficacy candidate in two different groups of patients who have overexpressed HER2 receptor with limited chemotherapeutic and other therapeutic treatments.

Merrimack also has MM-398 in its pipeline, which is currently in a phase III development for the second-line treatment of pancreatic cancer patients. Their disease has progressed after treatment with Eli Lilly and Company’s (LLY - Analyst Report) Gemzar (gemcitabine).

MM-398 was granted orphan drug designation by the European Medicines Agency (EMA) and U.S. Food and Drug Administration in 2011, for the treatment of pancreatic cancer. MM-398 is also being evaluated in other cancer indications.

Merrimack also has a license and collaboration agreement with Sanofi (SNY - Analyst Report) for developing another oncology candidate MM-121. MM-121 is being evaluated for multiple cancer indications. In May 2013, Merrimack completed the patient enrollment in a phase II study on MM-121 for the breast cancer indication.

Other early-stage pipeline candidates at Merrimack include MM-302, MM-151, MM-141. MM-302 is being developed for the treatment of breast cancer, while MM-151 and MM-141 are being developed for the treatment of solid tumors.

We note that Merrimack was recently in the news regarding its common stock and convertible senior notes offering. The company intends to use net proceeds from this offering to advance its pipeline.

Merrimack currently carries a Zacks Rank #4 (Sell). At present, in the biopharma space, companies like Jazz Pharmaceuticals (JAZZ - Analyst Report) look well positioned with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
ERBA DIAGNO… ERB 3.00 +3.09%
SANCHEZ ENE… SN 34.18 +2.67%
THE PANTRY… PTRY 21.02 +2.09%
INTEL CP INTC 35.15 +1.88%
CLAYTON WIL… CWEI 117.30 +1.78%