Back to top

Analyst Blog

The Medicines Company (MDCO - Analyst Report) recently announced the presentation and publication of a pooled analysis of three phase III studies conducted on its antiplatelet candidate, Cangrelor. The studies compared Cangrelor (intravenous) to Plavix (clopidogrel – oral) or placebo for the prevention of clotting complications during and after percutaneous coronary intervention (PCI).

The data from the pooled analysis of the CHAMPION program was similar to results from the CHAMPION PHOENIX trial. Cangrelor significantly cut the odds of the primary composite endpoint of death, myocardial infarction (MI), ischemia-driven revascularization (IDR) or stent thrombosis (ST) at 48 hours after randomization by 19% and stent thrombosis by 41%.

Meanwhile, The Medicines Co. said that the occurrence of clinically important major bleeding (measured by GUSTO and TIMI bleeding scales) was not increased with Cangrelor. However, higher bleeding was observed when more sensitive measures were used though there was no major difference in the rate of transfusions. Transient dyspnea was higher with Cangrelor compared to Plavix.

The pooled analysis was presented at the European Society of Cardiology and published in The Lancet as well.

We note that Cangrelor is currently under FDA review with a response expected in the second quarter of 2014. The Medicines Co. is looking to get Cangrelor approved for use in patients undergoing PCI and in patients requiring bridging from oral antiplatelet therapy to surgery. The Medicines Co. remains on track to file for EU approval of Cangrelor later this year.

The Medicines Co. currently carries a Zacks Rank #3 (Hold). At present, companies like Actelion Ltd. (ALIOF), Biogen Idec (BIIB - Analyst Report) and Gilead Sciences Inc. (GILD - Analyst Report) look attractive with all three being Zacks Rank #1 (Strong Buy) stocks.

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
UTD THERAPE… UTHR 117.83 +28.51%
TRIQUINT SE… TQNT 20.67 +6.52%
RF MICRO DE… RFMD 12.47 +6.04%
VASCO DATA… VDSI 14.77 +4.68%
BANCO DO BR… BDORY 15.53 +3.95%