Back to top

Analyst Blog

Actelion Ltd. (ALIOF) recently presented morbidity and mortality data on pipeline candidate, Opsumit, from a pivotal phase III study, SERAPHIN (Study with an Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome), at the European Respiratory Society Annual Congress.

The results from the trial (n=742) showed that the risk of a morbidity/mortality event was cut by 45% in pulmonary arterial hypertension (PAH) patients treated with Opsumit as compared to those on placebo.It was found that the effects of Opsumit seen earlier in the trial were sustained throughout.

Data from the study showed that Opsumit minimizes PAH related risk of hospitalization and death by 50% and all-cause mortality by 36% as compared to placebo.

The study revealed significant treatment effect in its secondary outcome measures for Opsumit as compared to placebo.

We note that Actelion is looking to get Opsumit approved for the treatment of patients suffering from PAH. Opsumit is currently under review in the U.S., EU and other countries.

Apart from PAH, Opsumit is also being evaluated in a pivotal phase III program in patients suffering from digital ulcers associated with systemic sclerosis. Results from this study are expected in 2014. In addition, Opsumit is being evaluated for the treatment of glioblastoma (phase I).

Actelion currently carries a Zacks Rank #1 (Strong Buy). Other stocks that look equally attractive include Biogen Idec Inc. (BIIB - Analyst Report) and Affymetrix Inc. (AFFX - Analyst Report), which carry a Zacks Rank #1. Gilead Sciences Inc. (GILD - Analyst Report) also looks well positioned with a Zacks Rank #2 (Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
ERBA DIAGNO… ERB 3.00 +3.09%
SANCHEZ ENE… SN 34.18 +2.67%
THE PANTRY… PTRY 21.02 +2.09%
INTEL CP INTC 35.15 +1.88%
PIPER JAFFR… PJC 54.54 +1.70%