Back to top

Analyst Blog

Shares of Repros Therapeutics Inc. (RPRX - Snapshot Report) reached a 52-week high of $28.30 in the first half of the trading session on Sep 17. Shares of the company soared following the announcement of  encouraging top-line data from the second pivotal efficacy study (ZA-302) and six-month safety study (ZA-300)  on its lead pipeline candidate, Androxal. The company is evaluating the use of Androxal for the treatment of men with secondary hypogonadism.

The ZA-302 study met both the primary endpoints. The results showed that 81% of the patients had average total testosterone in a normal range. The second primary endpoint was related to the drug’s impact on sperm concentration. Results did not reveal any harmful effects of Androxal on sperm function.

Repros also reported encouraging data from the ZA-300 study on Androxal. The company stated that Androxal was generally well-tolerated.

We note that earlier this year, the company had announced encouraging top-line data from the first pivotal phase III study (ZA-301). Both ZA-302 and ZA-301 were conducted under the FDA’s Special Protocol Assessment program.

The company is on track to file a New Drug Application to the U.S. Food and Drug Administration (FDA) for Androxal by mid 2014 with potential launch in 2015.

Currently prescribed therapies for secondary hypogonadism include AbbVie Inc.’s (ABBV - Analyst Report) AndroGel.

Repros currently carries a Zacks Rank #2 (Buy). We expect investor focus to remain on Androxal updates.

Currently, companies like Actelion Ltd. (ALIOF) and Biogen Idec Inc. (BIIB - Analyst Report) look more attractive with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
PLANAR SYST… PLNR 4.44 +5.21%
BITAUTO HOL… BITA 81.71 +5.12%
CTPARTNERS… CTP 16.66 +4.26%
CHINA BIOLO… CBPO 47.91 +3.30%
MALLINCKROD… MNK 72.94 +2.85%