Back to top

Analyst Blog

Alnylam Pharmaceuticals Inc. (ALNY - Analyst Report), a biopharmaceutical company, is focused on the development of novel therapeutics based on RNA (ribo nucleic acid) interference (RNAi). The company is developing several candidates using this technology for the treatment of multiple diseases.

Although most of the candidates at Alnylam are in early or mid-stages of development the company has progressed well with its pipeline in the recent past. ALN-PCSsc, a subcutaneously administered RNAi therapeutic, is an important candidate at Alnylam under the company’s ALN-PCS RNAi program. The candidate is being developed for the treatment of hypercholesterolemia.

Earlier this year, Alnylam had entered into a global alliance with The Medicines Co. (MDCO - Analyst Report) for the development and commercialization of the ALN-PCS RNAi program. The companies announced new data from non-human primate studies which revealed that ALN-PCSsc was successful in reducing PCSK9 by up to 90%. The candidate was also successful in reducing low-density lipoprotein (LDL) cholesterol in the absence of statins by up to 68%.

Alnylam and The Medicines Co. intend to file an investigative new drug application for the candidate in the U.S. towards the end of 2014.

As per the collaboration between the two companies, Alnylam will conduct pre-clinical and phase I studies following which The Medicines Co. will take up funding and development for the rest of the ALN-PCS program. The Medicines Co. will also be responsible for the commercialization of the ALN-PCS program, if successful.

We are encouraged by the pipeline progress at Alnylam. We expect investor focus to remain on the company’s pipeline.

Alnylam presently carries a Zacks Rank #4 (Sell). Stocks such as Endo Health Solutions Inc. (ENDP - Analyst Report) and Actelion Ltd. (ALIOF) currently look better positioned with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
SUPER MICRO… SMCI 26.16 +6.82%
STRATTEC SE… STRT 85.29 +6.29%
CENTURY ALU… CENX 26.34 +5.44%
BAIDU ADS BIDU 222.30 +3.63%
TESLA MOTOR… TSLA 279.46 +3.62%