Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at or call 800-767-3771 ext.  9339.

OncoGenex Pharmaceuticals, Inc. (OGXI - Snapshot Report) received encouraging news when the independent data monitoring committee (IDMC) recommended the continuation of the company’s phase III study (SYNERGY: n~1,023) on custirsen. The IDMC made its recommendation after completion of interim efficacy analysis of the data from the phase III trial.

The study is evaluating the survival benefit of the candidate, in combination with first-line Sanofi’s (SNY - Analyst Report) Taxotere (docetaxel), in metastatic castrate-resistant prostate cancer (CRPC) patients. OncoGenex expects final survival data from the study by mid 2014.

OncoGenex and partner Teva Pharmaceutical Industries, Ltd. (TEVA - Analyst Report) are blinded to all data from the SYNERGY trial. We note that in Dec 2009, OncoGenex entered into a collaboration agreement with Teva for the development and global commercialization of custirsen.

OncoGenex is also conducting the phase III AFFINITY study to evaluate the overall survival benefit of custirsen plus Sanofi’s Jevtana (cabazitaxel) as second-line chemotherapy in patients with metastatic CRPC. OncoGenex expects to complete enrollment by the end of 2014.

Custirsen is in another phase III study – ENSPIRIT –conducted in patients with advanced or metastatic non-small cell lung cancer (NSCLC). The study is evaluating the potential survival benefit of custirsen plus Taxotere as second-line chemotherapy.

Custirsen received Fast Track designation from the FDA for the treatment of progressive metastatic prostate cancer in combination with Taxotere and also for the second-line treatment of advanced NSCLC when combined with Taxotere in patients with disease progression.

OncoGenex carries a Zacks Rank #3 (Hold). Currently, Actelion Ltd. (ALIOF) looks well-positioned with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
DIXIE GRP IN DXYN 15.84 +7.90%
BOFI HLDG IN BOFI 85.30 +4.97%
RAMBUS INC RMBS 12.31 +4.41%
VIPSHOP HOLD VIPS 148.73 +4.35%
NETFLIX INC NFLX 345.74 +4.32%