Back to top

Analyst Blog

Ventrus Biosciences, Inc. focuses on developing and commercializing drugs for gastrointestinal treatments. The company’s lead candidate, VEN 307 (diltiazem hydrochloride 2% cream), is being developed for the treatment of anal fissures (AF).

Earlier in the week Ventrus completed patient enrollment and randomization of a phase III study (n= 434) on VEN 307. This is Ventrus’ second pivotal phase III study on VEN 307. The study, enrolment for which started in Oct 2012, is being conducted at 90 global clinical sites.

The randomized, double-blind, placebo-controlled, parallel-treatment group, multicenter study is evaluating the efficacy of VEN 307 in reducing severe AF-related pain during defecation when administered three times a day for 4 weeks. Ventrus is also evaluating the effects of VEN 307 in bringing down the daily overall AF-related pain. Patient global impression of improvement at the 29th day is also being evaluated.

Results from the study are expected in the first quarter of 2014. Ventrus intends to seek U.S. approval for the candidate in the following quarter (in the event of positive results from the pivotal study).

Ventrus successfully completed the first pivotal phase III study (n=465) on VEN 307 in May last year. Results from the study revealed significant improvements in average worst anal pain associated with or following defecation in patients under VEN 307 compared to placebo. An improvement in overall anal-fissure-related pain was also observed.

We note that diltiazem’s oral formulations are already approved for the treatment of angina and high blood pressure. As a result, VEN 307 is qualified for the FDA's 505(b)2 registration pathway.

Ventrus also has VEN 308 in its pipeline. The candidate is being developed for the treatment of fecal incontinence. We expect investor focus to remain on the company’s pipeline.

Ventrus presently carries a Zacks Rank #3 (Hold). Some better-ranked stocks include Jazz Pharmaceuticals (JAZZ - Analyst Report), Actelion Ltd. (ALIOF) and Lannett Company, Inc. (LCI - Snapshot Report). All these stocks carry a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
PLANAR SYST… PLNR 4.44 +5.21%
BITAUTO HOL… BITA 81.71 +5.12%
CTPARTNERS… CTP 16.66 +4.26%
CHINA BIOLO… CBPO 47.91 +3.30%
MALLINCKROD… MNK 72.94 +2.85%