Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at support@zacks.com or call 800-767-3771 ext.  9339.

Bristol-Myers Squibb Company (BMY - Analyst Report) and partner Otsuka America Pharmaceutical, Inc. presented four-year follow-up data from a phase III study (DASISION: n=519) on their leukemia drug Sprycel (dasatinib: 100 mg, once daily) at the annual meeting of the American Society of Hematology.

The phase III international study evaluated Sprycel’s efficacy and safety with that of  Novartis’ (NVS - Snapshot Report) Glivec (imatinib) as a first-line therapy in adults suffering from Philadelphia chromosome-positive (Ph+) chronic phase chronic myeloid leukemia (CP-CML).

Data revealed that 76% patients in the Sprycel arm achieved a major molecular response as opposed to 63% patients treated with Novartis’ cancer treatment. Moreover, 84% patients in the Sprycel arm achieved an optimal molecular response at three months, compared to 64% in the Glivec arm. Moreover, the safety profile of Sprycel in the follow up study was found to be consistent with that observed earlier in Ph+ CP-CML patients.

Sprycel is one of the key drugs in Bristol-Myers’ product portfolio. The drug performed impressively in the third quarter of 2013 with sales climbing 20% to $316 million. Apart from the long-term data on Sprycel, Bristol-Myers was in the news when the U.S. Food and Drug Administration (FDA) released the briefing documents ahead of the review by its Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) of the company’s candidate metreleptin (proposed trade name: Myalept) on Dec 11,2013.

Bristol-Myers, which has an agreement with AstraZeneca (AZN - Analyst Report) on the candidate, is looking to get it approved for treating metabolic disorders associated with lipodystrophy in pediatrics and adults suffering from the disease (not HIV related). Metreleptin has been granted priority review and a response from the FDA is expected by Feb 24, 2014. The content of the briefing documents highlighted that the candidate appeared to be beneficial only for a subgroup of patients. The candidate was not free from safety concerns as per the document. We believe investor focus will remain on updates regarding the candidate.

Bristol-Myers, a biopharmaceutical company, carries a Zacks Rank #3 (Hold). A better-ranked stock in the biopharma space is Actelion Ltd. (ALIOF) which carries a Zacks Rank #1 (Strong Buy).

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
DIXIE GRP IN DXYN 15.84 +7.90%
BOFI HLDG IN BOFI 85.30 +4.97%
RAMBUS INC RMBS 12.31 +4.41%
VIPSHOP HOLD VIPS 148.73 +4.35%
NETFLIX INC NFLX 345.74 +4.32%