Back to top

Analyst Blog

Shares of Cytokinetics, Inc. (CYTK - Snapshot Report) tumbled 64.7% after it announced that tirasemtiv failed to meet its primary endpoint in the phase IIb, BENEFIT-ALS (Blinded Evaluation of Neuromuscular Effects and Functional Improvement with Tirasemtiv in ALS) study.

Tirasemtiv is Cytokinetics’ lead candidate under its skeletal muscle contractility program.

The BENEFIT-ALS study evaluated the safety, tolerability and efficacy of tirasemtiv in patients suffering from amyotrophic lateral sclerosis (ALS). Enrolment in this study was completed in Dec 2013.

Cytokinetics recently reported top-line results from the BENEFIT-ALS study. The detailed results will be presented during the 66th Annual Meeting of the American Academy of Neurology (AAN) on Apr 29, 2014.

The BENEFIT-ALS study missed the primary endpoint of mean change in the ALS Functional Rating Scale from baseline in its revised form (ALSFRS-R) on tirasemtiv against placebo in the study (-2.98 points (tirasemtiv) versus -2.40 points (placebo). The secondary efficacy endpoints showed mixed results.

Once the complete data from the BENEFIT-ALS study is available, the company will review and evaluate the same. Cytokinetics will then arrive at a decision regarding the development path of the candidate.

The failure of the candidate is disappointing news for Cytokinetics, as it was the lead candidate under its skeletal muscle contractility program.

Cytokinetics currently carries a Zacks Rank #3 (Hold). Investors looking for better-ranked stocks in the biopharma sector may consider companies like Questcor Pharmaceuticals, Inc. , Alexion Pharmaceuticals, Inc. (ALXN - Analyst Report) and Sucampo Pharmaceuticals, Inc. (SCMP - Snapshot Report). Questcor and Sucampo carry a Zacks Rank #1 (Strong Buy) while Alexion carries a Zacks Rank #2 (Buy).

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
PLANAR SYST… PLNR 4.44 +5.21%
BITAUTO HOL… BITA 81.71 +5.12%
CTPARTNERS… CTP 16.66 +4.26%
CHINA BIOLO… CBPO 47.91 +3.30%
MALLINCKROD… MNK 72.94 +2.85%