Back to top

Analyst Blog

Sanofi (SNY - Analyst Report) and partner Regeneron Pharmaceuticals, Inc. (REGN - Analyst Report) presented positive results from a phase III trial, SARIL-RA-MOBILITY, on pipeline candidate sarilumab.

Both the companies are evaluating the safety and efficacy of sarilumab in patients suffering from rheumatoid arthritis (RA) who have not shown adequate response to methotrexate (MTX) therapy.

We note that sarilumab was developed using Regeneron's VelocImmune antibody technology.

The data from the study showed that sarilumab increased significant clinical response rates for at least 24 consecutive weeks. In addition, treatment with sarilumab showed sustained improvement in signs and symptoms of RA after 52 weeks, thereby achieving the secondary endpoints of the trial.

It was also observed in the trial that sarilumab demonstrated efficacy at two different doses, both delivered subcutaneously every other week.

We remind investors that sarilumab had met all three co-primary endpoints of the trial in Nov 2013.

We note that Sanofi and Regeneron are conducting a SARIL-RA phase III development program to evaluate the use of sarilumab in the RA indication. The program consists of five trials, namely, SARIL-RA MOBILITY, SARIL-RA TARGET, SARIL-RA COMPARE, SARILRA ASCERTAIN and SARIL-RA EXTEND.

Sanofi carries a Zacks Rank #3 (Hold). We are encouraged by Sanofi’s efforts to develop its pipeline. Sanofi is facing generic threats for most of its key drugs. Hence, the successful development and commercialization of new products will offset the negative impact of generics on revenues.

Some better-ranked stocks in the health care sector include Allergan (AGN - Analyst Report) and Gilead Sciences (GILD - Analyst Report). Both carry a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
UTD THERAPE… UTHR 117.83 +28.51%
TRIQUINT SE… TQNT 20.67 +6.52%
RF MICRO DE… RFMD 12.47 +6.04%
VASCO DATA… VDSI 14.77 +4.68%
BANCO DO BR… BDORY 15.53 +3.95%