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Epizyme (EPZM) Publishes Tazemetostat Phase I Data, Stock Up
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Shares of Epizyme Inc. rose almost 10% after the company announced the publication of tazemetostat phase I clinical data in The Lancet Oncology. The study demonstrated favorable safety findings and anti-tumor activity and established recommended dose for the phase II expansion study.
The phase I study was designed to evaluate the maximally tolerated dose and supported defining the recommended phase II dose (RP2D) of tazemetostat-a first-in-class selective inhibitor of EZH2.
Over a year, shares of Epizyme have returned 4.2%, as against the industry’s decline of 7.7%.
The phase I dose-escalation portion of the study evaluated the safety and tolerability of orally dosed tazemetostat. Tazemetostat was dosed twice daily as a single agent in patients with relapsed or refractory B-cell NHL (n=21) or with advanced solid tumors (n=43) including molecularly defined INI1- or SMARCA4-negative tumors.
Additional studies evaluated the adverse events, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of the agent. The results from these studies helped in determining the RP2D of 800 mg twice daily.
Anti-tumor activity was seen across several tumor types. In B-cell NHL, durable objective responses were observed in eight patients. Three patients had a complete response, one with diffuse large B-cell lymphoma (“DLBCL”) and two with follicular lymphoma (“FL”).
We note that, Epizyme is developing its lead product candidate, tazemetostat for a wide range of hematological malignancies. Tazemetostat, is being evaluated for both solid tumors and hematological malignancies, as a monotherapy and combination therapy in relapsed and front-line disease.
It is currently being studied as a monotherapy in ongoing phase II programs in certain molecularly defined solid tumors, including epithelioid sarcoma and other INI1-negative tumors; both FL and DLBCL forms of non-Hodgkin lymphoma; mesothelioma; and combination studies in DLBCL and NSCLC.
A potential approval of the candidate will be significant boost for the company.
A few better-ranked stocks from the same space worth considering are Ligand Pharmaceuticals (LGND - Free Report) , Protagonist Therapeutics (PTGX - Free Report) and Catabasis Pharmaceuticals . Whlle Ligand and Protagonist sport a Zacks Rank #1 (Strong Buy), Catabasis carries a Zacks Rank#2 (Buy).You can see the complete list of today’s Zacks #1 Rank stocks here.
Ligand’s earnings per share estimates have moved up $3.78 to $4.20 from $4.75 to $5.32 for 2018 and 2019, respectively, over the last 60 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.88%. The company’s shares have rallied 54.6% over a year.
Protagonist’s loss estimates narrowed from $1.30 to 66 cents for 2018 and from $1.99 to $1.26 for 2019, over the last 30 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.95%.
Catabasis’ loss estimates narrowed from $1.09 to 92 cents for 2018 and from $1.76 to $1.48 for 2019, in the last 30 days. The company came up with a positive earnings surprise in all the preceding four quarters, with an average beat of 14.56%. The stock has rallied 22.2% so far this year.
5 Medical Stocks to Buy Now
Zacks names 5 companies poised to ride a medical breakthrough that is targeting cures for leukemia, AIDS, muscular dystrophy, hemophilia, and other conditions. New products in this field are already generating substantial revenue and even more wondrous treatments are in the pipeline. Early investors could realize exceptional profits.
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Epizyme (EPZM) Publishes Tazemetostat Phase I Data, Stock Up
Shares of Epizyme Inc. rose almost 10% after the company announced the publication of tazemetostat phase I clinical data in The Lancet Oncology. The study demonstrated favorable safety findings and anti-tumor activity and established recommended dose for the phase II expansion study.
The phase I study was designed to evaluate the maximally tolerated dose and supported defining the recommended phase II dose (RP2D) of tazemetostat-a first-in-class selective inhibitor of EZH2.
Over a year, shares of Epizyme have returned 4.2%, as against the industry’s decline of 7.7%.
The phase I dose-escalation portion of the study evaluated the safety and tolerability of orally dosed tazemetostat. Tazemetostat was dosed twice daily as a single agent in patients with relapsed or refractory B-cell NHL (n=21) or with advanced solid tumors (n=43) including molecularly defined INI1- or SMARCA4-negative tumors.
Additional studies evaluated the adverse events, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of the agent. The results from these studies helped in determining the RP2D of 800 mg twice daily.
Anti-tumor activity was seen across several tumor types. In B-cell NHL, durable objective responses were observed in eight patients. Three patients had a complete response, one with diffuse large B-cell lymphoma (“DLBCL”) and two with follicular lymphoma (“FL”).
We note that, Epizyme is developing its lead product candidate, tazemetostat for a wide range of hematological malignancies. Tazemetostat, is being evaluated for both solid tumors and hematological malignancies, as a monotherapy and combination therapy in relapsed and front-line disease.
It is currently being studied as a monotherapy in ongoing phase II programs in certain molecularly defined solid tumors, including epithelioid sarcoma and other INI1-negative tumors; both FL and DLBCL forms of non-Hodgkin lymphoma; mesothelioma; and combination studies in DLBCL and NSCLC.
A potential approval of the candidate will be significant boost for the company.
Epizyme, Inc. Price
Epizyme, Inc. Price | Epizyme, Inc. Quote
Zacks Ranks and Stocks to Consider
Epizyme carries a Zacks Rank #3 (Hold).
A few better-ranked stocks from the same space worth considering are Ligand Pharmaceuticals (LGND - Free Report) , Protagonist Therapeutics (PTGX - Free Report) and Catabasis Pharmaceuticals . Whlle Ligand and Protagonist sport a Zacks Rank #1 (Strong Buy), Catabasis carries a Zacks Rank#2 (Buy).You can see the complete list of today’s Zacks #1 Rank stocks here.
Ligand’s earnings per share estimates have moved up $3.78 to $4.20 from $4.75 to $5.32 for 2018 and 2019, respectively, over the last 60 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.88%. The company’s shares have rallied 54.6% over a year.
Protagonist’s loss estimates narrowed from $1.30 to 66 cents for 2018 and from $1.99 to $1.26 for 2019, over the last 30 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.95%.
Catabasis’ loss estimates narrowed from $1.09 to 92 cents for 2018 and from $1.76 to $1.48 for 2019, in the last 30 days. The company came up with a positive earnings surprise in all the preceding four quarters, with an average beat of 14.56%. The stock has rallied 22.2% so far this year.
5 Medical Stocks to Buy Now
Zacks names 5 companies poised to ride a medical breakthrough that is targeting cures for leukemia, AIDS, muscular dystrophy, hemophilia, and other conditions. New products in this field are already generating substantial revenue and even more wondrous treatments are in the pipeline. Early investors could realize exceptional profits.
Click here to see the 5 stocks >>