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Alnylam's (ALNY) Q1 Loss Wider than Expected, Sales Miss
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Alnylam Pharmaceuticals, Inc. (ALNY - Free Report) incurred a loss of $1.22 per share (excluding stock based compensation expense), wider than the year ago loss of $1.06 per share and wider than the Zacks Consensus Estimate of a loss of $1.18
Quarterly revenues improved 15.3% to $21.9 million, but missed the Zacks Consensus Estimate of $36 million. The top line in the quarter included $18.9 million earned under the company's collaboration agreement with Sanofi’s (SNY - Free Report) subsidiary, Genzyme as well as $1.3 million from the company’s alliance with The Medicines Company and $1.7 million from other sources.
Quarter in Detail
Adjusted research and development (R&D) expenses increased 10.7% from the year-ago period to $86.7 million. Adjusted general and administrative (G&A) expenses doubled from the year ago quarter to $63 million.
2018 Guidance
Alnylam remains on track to end the year with approximately $1 billion in cash, cash equivalents and fixed income marketable. Adjusted R&D expenses are expected in the range of $420 to $460 million up from the prior guidance of $400 million to $440 million. The company reiterated its outlook for adjusted selling, general and administrative expenses and expects them to be in the range of $280 million to $320 million.
Pipeline Updates
Alnylam received acceptance from the FDA and the European Medicines Agency (EMA) of patisiran’s new drug application (NDA) and Marketing Authorisation Application (MAA), respectively. Patisiran is an investigational RNAi therapeutic for the treatment of patients with hereditary ATTR (hATTR) amyloidosis with polyneuropathy.
The company expects to gain regulatory approval for patisiran from the FDA in mid-2018. The FDA has set an action date of Aug 11, 2018, and launch patisiran in the United States shortly after that.
Alnylam expects to report topline interim results from the ENVISION Phase III trial for givosiran by September 2018. The company also expects to initiate the lumasiran phase III study in mid-2018.
The company announced a strategic restructuring of the its rare disease alliance with Sanofi, originally formed in 2014, with Alnylam obtaining global rights to its ATTR amyloidosis programs – patisiran and ALN-TTRsc02 – and Sanofi obtaining global rights to fitusiran. Alnylam and Sanofi expect to enroll patients in the ATLAS phase III program of fitusiran in patients with hemophilia A and B with or without inhibitors throughout the year.
Our Take
Alnylam posted wider than expected loss and missed revenue estimates in the first quarter of 2018. With several pipeline related events lined up and potential approval for patisiran, we expect investor focus to remain on the related updates.
Shares of the company rose more than 1.4% in after-hours trading owing to the strong quarterly results. However, year to date, Alnylam’s shares price have lost 30.5%, compared with a 13% decline for the industry.
Ligand’s earnings per share estimates have moved up $4.20 to $4.43 for 2018 over the last 30 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.88%. The company’s shares have rallied 14.6% year to date.
Alnylam Pharmaceuticals, Inc. Price, Consensus and EPS Surprise
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Alnylam's (ALNY) Q1 Loss Wider than Expected, Sales Miss
Alnylam Pharmaceuticals, Inc. (ALNY - Free Report) incurred a loss of $1.22 per share (excluding stock based compensation expense), wider than the year ago loss of $1.06 per share and wider than the Zacks Consensus Estimate of a loss of $1.18
Quarterly revenues improved 15.3% to $21.9 million, but missed the Zacks Consensus Estimate of $36 million. The top line in the quarter included $18.9 million earned under the company's collaboration agreement with Sanofi’s (SNY - Free Report) subsidiary, Genzyme as well as $1.3 million from the company’s alliance with The Medicines Company and $1.7 million from other sources.
Quarter in Detail
Adjusted research and development (R&D) expenses increased 10.7% from the year-ago period to $86.7 million. Adjusted general and administrative (G&A) expenses doubled from the year ago quarter to $63 million.
2018 Guidance
Alnylam remains on track to end the year with approximately $1 billion in cash, cash equivalents and fixed income marketable. Adjusted R&D expenses are expected in the range of $420 to $460 million up from the prior guidance of $400 million to $440 million. The company reiterated its outlook for adjusted selling, general and administrative expenses and expects them to be in the range of $280 million to $320 million.
Pipeline Updates
Alnylam received acceptance from the FDA and the European Medicines Agency (EMA) of patisiran’s new drug application (NDA) and Marketing Authorisation Application (MAA), respectively. Patisiran is an investigational RNAi therapeutic for the treatment of patients with hereditary ATTR (hATTR) amyloidosis with polyneuropathy.
The company expects to gain regulatory approval for patisiran from the FDA in mid-2018. The FDA has set an action date of Aug 11, 2018, and launch patisiran in the United States shortly after that.
Alnylam expects to report topline interim results from the ENVISION Phase III trial for givosiran by September 2018. The company also expects to initiate the lumasiran phase III study in mid-2018.
The company announced a strategic restructuring of the its rare disease alliance with Sanofi, originally formed in 2014, with Alnylam obtaining global rights to its ATTR amyloidosis programs – patisiran and ALN-TTRsc02 – and Sanofi obtaining global rights to fitusiran. Alnylam and Sanofi expect to enroll patients in the ATLAS phase III program of fitusiran in patients with hemophilia A and B with or without inhibitors throughout the year.
Our Take
Alnylam posted wider than expected loss and missed revenue estimates in the first quarter of 2018. With several pipeline related events lined up and potential approval for patisiran, we expect investor focus to remain on the related updates.
Shares of the company rose more than 1.4% in after-hours trading owing to the strong quarterly results. However, year to date, Alnylam’s shares price have lost 30.5%, compared with a 13% decline for the industry.
Zacks Rank & Stocks to Consider
Alnylam is a Zacks Rank #3 (Hold) stock.
Another better-ranked stock from the same space worth considering is Ligand Pharmaceuticals (LGND - Free Report) , sporting a Zacks Rank #1 (Strong Buy).You can see the complete list of today’s Zacks #1 Rank stocks here.
Ligand’s earnings per share estimates have moved up $4.20 to $4.43 for 2018 over the last 30 days. The company delivered a positive earnings surprise in three of the trailing four quarters, with an average beat of 24.88%. The company’s shares have rallied 14.6% year to date.
Alnylam Pharmaceuticals, Inc. Price, Consensus and EPS Surprise
Alnylam Pharmaceuticals, Inc. Price, Consensus and EPS Surprise | Alnylam Pharmaceuticals, Inc. Quote
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And this outperformance has not just been a recent phenomenon. Over the years it has been remarkably consistent. From 2000 - 2017, the composite yearly average gain for these strategies has beaten the market more than 19X over. Maybe even more remarkable is the fact that we're willing to share their latest stocks with you without cost or obligation.
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