We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies, revised Privacy Policy and Terms of Service.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Seattle Genetics Closes Enrollment in Cervical Cancer Study
Read MoreHide Full Article
Seattle Genetics, Inc. announced that it has completed enrollment in the phase II innovaTV 204 study on its pipeline candidate, tisotumab vedotin. The candidate is being evaluated as a monotherapy for the treatment of patients with advanced/metastatic cervical cancer, whose disease relapsed or progressed after the standard of care treatment.
Tisotumab vedotin is being developed in partnership with the Danish company, Genmab A/S (GNMSF - Free Report) . The candidate is an antibody-drug conjugate (ADC), targeting the tissue factor antigen that delivers the cell-killing agent monomethyl auristatin E (MMAE) inside cancer cells.
This pivotal phase II program will support the candidate’s potential registration under the FDA's accelerated approval pathway for the given indication. On the fourth-quarter conference call, the company mentioned that it planned to complete its enrollment by mid-2019. This news comes slightly earlier-than-the-previously-expected time.
Notably, last June 2018, Seattle Genetics initiated the phase II innovaTV 204 evaluation of tisotumab vedotin for the given patient population. The candidate is also being evaluated for several other cancer types, both as a monotherapy and a combo regime. Currently, tisotumab vedotin is examined in a phase I/II probe in combination with other cancer agents for treating the first/second-line metastatic cervical cancer. Two other phase II studies are investigating the candidate for advanced solid tumors and platinum-resistant ovarian cancer.
Shares of Seattle Genetics have rallied 29.3% so far this year, outperforming the industry’s increase of 12.5%.
We would like to remind investors that last week, Seattle Genetics and its Japanese partner Astellas Pharma announced positive top-line results from the first cohort of the phase II EV-201 study on enfortumab vedotin. The candidate is being evaluated for addressing patients with advanced/metastatic urothelial cancer, who were previously treated with both a checkpoint inhibitor (PD-1/PD-L1) and platinum-based chemotherapy.
Both companies plan to submit a biologics license application (BLA) to the FDA for enfortumab vedotin later this year.
Another interesting candidate in Seattle Genetics’ portfolio is SEA-BCMA, which is being assessed in a phase I study for treating patients with relapsed or refractory multiple myeloma (MM).
Zacks Rank & Stocks to Consider
Seattle Genetics currently carries a Zacks Rank #5 (Strong Sell).
Celgene’s earnings estimates have been revised 1.5% upward for 2019 and 2.2% for 2020 over the past 60 days. The stock has surged 47.2% in the year so far.
Kamada’s earnings estimates have moved 34.3% north for 2019 and 5% for 2020 over the past 60 days. The stock has risen 14.6% so far this year.
Zacks' Top 10 Stocks for 2019
In addition to the stocks discussed above, wouldn't you like to know about our 10 finest buy-and-holds for the year?
From more than 4,000 companies covered by the Zacks Rank, these 10 were picked by a process that consistently beats the market. Even during 2018 while the market dropped -5.2%, our Top 10s were up well into double-digits. And during bullish 2012 – 2017, they soared far above the market's +126.3%, reaching +181.9%.
This year, the portfolio features a player that thrives on volatility, an AI comer, and a dynamic tech company that helps doctors deliver better patient outcomes at lower costs.
Image: Bigstock
Seattle Genetics Closes Enrollment in Cervical Cancer Study
Seattle Genetics, Inc. announced that it has completed enrollment in the phase II innovaTV 204 study on its pipeline candidate, tisotumab vedotin. The candidate is being evaluated as a monotherapy for the treatment of patients with advanced/metastatic cervical cancer, whose disease relapsed or progressed after the standard of care treatment.
Tisotumab vedotin is being developed in partnership with the Danish company, Genmab A/S (GNMSF - Free Report) . The candidate is an antibody-drug conjugate (ADC), targeting the tissue factor antigen that delivers the cell-killing agent monomethyl auristatin E (MMAE) inside cancer cells.
This pivotal phase II program will support the candidate’s potential registration under the FDA's accelerated approval pathway for the given indication. On the fourth-quarter conference call, the company mentioned that it planned to complete its enrollment by mid-2019. This news comes slightly earlier-than-the-previously-expected time.
Notably, last June 2018, Seattle Genetics initiated the phase II innovaTV 204 evaluation of tisotumab vedotin for the given patient population. The candidate is also being evaluated for several other cancer types, both as a monotherapy and a combo regime. Currently, tisotumab vedotin is examined in a phase I/II probe in combination with other cancer agents for treating the first/second-line metastatic cervical cancer. Two other phase II studies are investigating the candidate for advanced solid tumors and platinum-resistant ovarian cancer.
Shares of Seattle Genetics have rallied 29.3% so far this year, outperforming the industry’s increase of 12.5%.
We would like to remind investors that last week, Seattle Genetics and its Japanese partner Astellas Pharma announced positive top-line results from the first cohort of the phase II EV-201 study on enfortumab vedotin. The candidate is being evaluated for addressing patients with advanced/metastatic urothelial cancer, who were previously treated with both a checkpoint inhibitor (PD-1/PD-L1) and platinum-based chemotherapy.
Both companies plan to submit a biologics license application (BLA) to the FDA for enfortumab vedotin later this year.
Another interesting candidate in Seattle Genetics’ portfolio is SEA-BCMA, which is being assessed in a phase I study for treating patients with relapsed or refractory multiple myeloma (MM).
Zacks Rank & Stocks to Consider
Seattle Genetics currently carries a Zacks Rank #5 (Strong Sell).
Better-ranked stocks in the healthcare sector include Celgene Corporation and Kamada Ltd. , both sporting a Zacks Rank #1 (Strong Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.
Celgene’s earnings estimates have been revised 1.5% upward for 2019 and 2.2% for 2020 over the past 60 days. The stock has surged 47.2% in the year so far.
Kamada’s earnings estimates have moved 34.3% north for 2019 and 5% for 2020 over the past 60 days. The stock has risen 14.6% so far this year.
Zacks' Top 10 Stocks for 2019
In addition to the stocks discussed above, wouldn't you like to know about our 10 finest buy-and-holds for the year?
From more than 4,000 companies covered by the Zacks Rank, these 10 were picked by a process that consistently beats the market. Even during 2018 while the market dropped -5.2%, our Top 10s were up well into double-digits. And during bullish 2012 – 2017, they soared far above the market's +126.3%, reaching +181.9%.
This year, the portfolio features a player that thrives on volatility, an AI comer, and a dynamic tech company that helps doctors deliver better patient outcomes at lower costs.
See Stocks Today >>