Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at support@zacks.com or call 800-767-3771 ext.  9339.

Alnylam Pharmaceuticals, Inc. (ALNY - Analyst Report) recently presented complete results from a phase IIb trial on ALN-RSV01 at the European Respiratory Society’s (ERS) Annual Meeting. The candidate failed to achieve the primary end point of the phase IIb trial.

However, the candidate demonstrated significant treatment effect. Alnylam will provide an update on its development plans for ALN-RSV01’s by the end of 2012 after discussing the complete results from the trial with regulatory authorities.

The randomized, double-blind, placebo-controlled phase IIb trial enrolled 87 patients. The reduction in the occurrence of new or progressive bronchiolitis obliterans syndrome (BOS) at 180 days was the primary endpoint of the trial, which the candidate failed to achieve. However, the candidate showed a statistically significant reduction in BOS at 90 days and was found to be generally safe and well tolerated in the trial.   

Alnylam has collaborated with Kyowa Hakko Kirin Co. for the development of ALN-RSV01 in Asia and with Cubist Pharmaceuticals Inc. (CBST - Analyst Report) in the rest of the world.

Alnylam makes use of the potentially revolutionary RNAi technology, a natural cellular process for selectively turning off the activity of genes, to build a pipeline to treat a wide array of diseases. In January 2011, Alnylam launched its “Alnylam 5X15” strategy aimed at developing RNAi therapeutic products for the treatment of genetically defined diseases addressing major unmet medical needs.

Alnylam expects to have five such RNAi therapeutic programs in advanced clinical development by the end of 2015. We expect investor focus to remain on the company’s pipeline progress.

The major programs under development are ALN-PCS (hypercholesterolemia), second generation ALN-TTR (transthyretin/TTR-mediated amyloidosis/ATTR), ALN-HPN (refractory anemia), ALN-AT3 (hemophilia) and ALN-TMP (hemoglobinopathies).

Alnylam also has collaborations or deals with players, such as Novartis AG (NVS - Snapshot Report), Biogen Idec Inc. (BIIB - Analyst Report) and Roche Holding AG (RHHBY - Analyst Report) to further develop and utilize its core technology.

The stock carries a Zacks #3 Rank (Hold rating) in the short run.

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
DIXIE GRP IN DXYN 15.84 +7.90%
BOFI HLDG IN BOFI 85.30 +4.97%
RAMBUS INC RMBS 12.31 +4.41%
VIPSHOP HOLD VIPS 148.73 +4.35%
NETFLIX INC NFLX 345.74 +4.32%