Back to top

Analyst Blog

Switzerland-based pharmaceutical company Novartis AG (NVS - Analyst Report) recently announced positive data on Lucentis (ranibizumab), which showed that individualized treatment with the drug can improve eyesight even with a lower number of injections.

Novartis also presented positive data on Lucentis from a study (REPAIR) conducted in with visual impairment due to choroidal neovascularization (CNV) secondary to pathological myopia (PM).

The study, which was conducted with 65 patients, showed that 6 months of treatment with 0.5 mg Lucentis helped improve the mean visual acuity by twelve letters.

The study also showed that 29% of the patients did not require additional treatments after receiving the first injection.

Novartis plans to seek regulatory approval of Lucentis for myopic CNV in EU in the third quarter of 2012 and in Japan by year end.

The only approved medication for this indication is photodynamic therapy with QLT Inc.’s (QLTI - Analyst Report) Visudyne (verteporfin).

In the RESTORE extension study, 240 patients suffering from diabetic macular edema (DME) received an average of 13.9 injections of Lucentis individualized treatment for three years. Results demonstrated that about 19−25% of the patients participating in the study did not require further injections of Lucentis after the first year.

The study also confirmed the drug’s long-term efficacy and safety profile in patients with wet age-related macular degeneration (wet AMD) and DME.

Results showed that in order to maintain the mean visual acuity gained in the core study, an average of 3.7 injections and 2.7 injections were required in the second and third years, respectively. 

Meanwhile, the retrospective analysis of the LUMINOUS program, which currently comprises of more than 10,000 patients, reaffirmed the safety profile of Lucentis in wet AMD.

Lucentis is currently approved for wet AMD, visual impairment due to DME and visual impairment due to macular edema following retinal vein occlusion (RVO). The drug was developed by Novartis in partnership with Roche Holdings Ltd. (RHHBY - Analyst Report).

Roche holds the US marketing rights of the drug. In the second quarter of 2012, Novartis recorded Lucentis sales of $604 million, up 20% year over year in local currency.

Our Recommendation

Currently, we have a Neutral recommendation on Novartis. The company carries a Zacks #3 Rank (Hold rating) in the short run.

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
RPC INC RES 24.91 +8.35%
LITHIA MOTO… LAD 94.59 +4.60%
DELTA AIR L… DAL 39.15 +3.90%
FLAMEL TECH… FLML 14.51 +3.50%
SOUTHWEST A… LUV 28.87 +2.92%