Back to top

Analyst Blog

Peregrine Pharmaceuticals (PPHM - Snapshot Report) recently announced phase II data on its oncology candidate, bavituximab. The open-label, randomized phase II study was conducted in patients suffering from previously untreated, advanced Stage IV pancreatic cancer.

The study compared bavituximab plus Eli Lilly’s (LLY - Analyst Report) Gemzar (gemcitabine) to Gemzar alone. Results showed that patients in the combination arm had a 28% tumor response rate compared to 13% in the Gemzar arm. However, median overall survival, which was the primary endpoint, was modest at 5.6 months for the combination arm versus 5.2 months for the Gemzar arm.

Bavituximab in combination with Gemzar was found to be safe and well tolerated with similar adverse events occurring in both arms.

Peregrine Pharma intends to analyze the results further and present the same at a scientific meeting later this year.

Bavituximab is a key pipeline candidate at Peregrine Pharma. Bavituximab is being studied for several indications including non-small cell lung cancer in the front and second-line settings, breast, prostate, liver and rectal cancers in combination with approved chemotherapies and radiation.

We note that last year, the company had presented results on bavituximab from a phase II study for second-line non-small cell lung cancer. However, later on, Peregrine Pharma had said that the data could not be relied on due to certain discrepancies between some patient sample test results and patient treatment code assignments.

Earlier this year, Peregrine Pharma provided an update on the situation and provided information from an internal review of the discrepancies.

The company said that discrepancies were isolated to the placebo and 1 mg/kg treatment arms of the trial with no evidence of discrepancies in the 3 mg/kg treatment arm of the trial. Peregrine Pharma intends to announce detailed results from the analysis shortly.

Peregrine Pharma currently carries a Zacks Rank #3 (Hold). We expect investor focus to remain on updates on the future development path for bavituximab. Biopharma companies that currently look more attractive include Cytokinetics, Inc. (CYTK - Snapshot Report) and Targacept, Inc. (TRGT - Snapshot Report). Both are Zacks Rank #1 stocks (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
PLANAR SYST… PLNR 4.44 +5.21%
BITAUTO HOL… BITA 81.71 +5.12%
CTPARTNERS… CTP 16.66 +4.26%
CHINA BIOLO… CBPO 47.91 +3.30%
MALLINCKROD… MNK 72.94 +2.85%