Back to top

Analyst Blog

Novartis (NVS - Analyst Report) recently announced that the US Food and Drug Administration (FDA) has approved Simbrinza Suspension for the reduction of elevated intraocular pressure (IOP) in patients suffering from primary open-angle glaucoma or ocular hypertension.

We note that the only modifiable risk factor for glaucoma, which leads to blindness, is elevated IOP. Novartis stated in its press release that glaucoma is the second-leading cause of preventable blindness across the globe.

Simbrinza combines brinzolamide and brimonidine tartrate. The FDA approval was based on encouraging data from two pivotal phase III studies (n=1300) wherein Simbrinza was evaluated for safety and efficacy for over three months.

We are encouraged by the recent bout of regulatory approvals at Novartis. In Mar 2013, the European Commission approved Jetrea intravitreal injection (ocriplasmin) for the treatment of vitreomacular traction (VMT) and macular hole.

Affecting 250,000 to 300,000 people in Europe, VMT causes sight-threatening symptoms, which might result in irreversible vision loss. So far, people suffering from VMT had only surgery as a treatment option for this eye disease.

The approval was based on results from pivotal studies, which demonstrated that patients treated with Jetrea successfully achieved resolution of VMT and closure of macular holes compared to placebo on the 28th day of treatment.

We note that Novartis caters to the eyecare market through its division Alcon, which accounted for 18% of total sales in 2012. The recent approvals should further boost segmental sales.

Novartis carries a Zacks Rank #3 (Hold). Pharma stocks, which currently look more attractive include Vertex Pharmaceuticals (VRTX - Analyst Report), UCB SA (UCBJF) and Alnylam Pharmaceuticals (ALNY - Analyst Report). All three carry a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
GTT COMMUNI… GTT 11.65 +4.11%
ALLERGAN IN… AGN 161.82 +3.99%
CLAYTON WIL… CWEI 117.06 +3.73%
GREENBRIER… GBX 69.63 +2.37%
RF MICRO DE… RFMD 12.02 +2.04%