Back to top

Analyst Blog

Isis Pharmaceuticals Inc. (ISIS - Analyst Report) recently announced that it has received a milestone payment of $3.5 million from its partner, Biogen Idec Inc. (BIIB - Analyst Report). The milestone payment was triggered by dosing of the first patient in a phase II study evaluating ISIS-SMNin infants suffering from spinal muscular atrophy (SMA).

The open-label, multiple-dose, dose-escalation pilot phase II study will be conducted in eight infants (between three weeks and seven months) for the treatment of SMA. ISIS-SMN enjoys orphan drug as well as fast track status with the US Food and Drug Administration (FDA).

We remind investors that in Mar 2013, data from an open-label phase I study evaluating ISIS-SMN in children with SMA was presented. Results showed that ISIS-SMN was well tolerated at all the evaluated dose levels. Additionally, improvements in Hammersmith scores were also observed.

Isis Pharma is also evaluating ISIS-SMN in a multiple-dose phase Ib/2a study. The company expects to report data from this study by late 2013 or early 2014. Isis Pharma intends to initiate phase II/III studies on ISIS-SMN in infants in 2013 and children in the first half of 2014.

We note that as per the terms of the Isis Pharma-Biogen agreement, inked in Jan 2012, Isis Pharma is responsible for the global development of ISIS-SMN through the completion of phase II/III registrational studies, with input from Biogen. The latter will take over global development, regulatory and commercialization responsibilities if it decides to exercise its option. Biogen has the option to license ISIS-SMN until completion of the first successful phase II/III trial.

Isis Pharma currently carries a Zacks Rank #2 (Buy). Stocks such as Lannett Company, Inc. (LCI - Snapshot Report) and Alkermes plc (ALKS - Analyst Report) look equally attractive with a Zacks Rank #2.

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
ERBA DIAGNO… ERB 3.00 +3.09%
SANCHEZ ENE… SN 34.18 +2.67%
THE PANTRY… PTRY 21.01 +2.04%
CLAYTON WIL… CWEI 117.57 +2.01%
INTEL CP INTC 35.14 +1.86%