With assets of $214.57 billion as of Dec 31, 2023, Cincinnati-based Fifth Third Bancorp has 1,088 full-service banking centers in 11 states throughout the Midwestern and Southeastern regions of the United States. In 2019, Fifth Third received the Office of the Comptroller of the Currency's approval to convert from an Ohio state-chartered bank to a national bank.

Fifth Third classifies its operations into mainly four reportable segments. Firstly, Branch Banking provides deposit and loan products, and credit cards to individuals and small businesses. Next, Consumer Lending includes residential mortgage, automobile and other indirect lending activities.

The Commercial Banking unit provides credit intermediation, cash management and financial services to large and middle-market businesses, governments and professional customers. The Wealth and Asset Management division offers provides a full range of wealth management services to individuals, companies and non-profit organizations.

The General Corporate and Other segment includes unallocated portion of investment securities portfolio, securities gains and losses, non-core deposit funding, unassigned equity, unallocated provision for credit losses expense or benefit from reduction of allowance for loan losses, the payment of preferred stock dividends and certain support activities and other items not attributed to the business segments.

In 2023, Fifth Third acquired Rize Money to expand its offerings in the embedded payment space. It also acquired Big Data LLC to enhance the range of services associated with the financial aspects of national healthcare. In 2022, the company acquired Dividend Finance in a bid to grow its digital service capabilities. In 2021, it completed the buyout of Provide, a digital platform for healthcare practices and Hammond Hanlon Camp LLC. In 2019, 2018 and 2017, the company completed the acquisition of MB Financial, Coker Capital, a healthcare Merger & Acquisition advisory firm, and R.G. McGraw Insurance Agency, respectively.