Back to top

Image: Bigstock

Bayer's Drug Meets Primary Endpoint in Renal Outcomes Study

Read MoreHide Full Article

Bayer Aktiengesellschaft (BAYRY - Free Report) announced that its investigational candidate, finerenone, met the primary endpoint in a phase III study, FIDELIO-DKD. The study evaluated the efficacy and safety of finerenone versus placebo when added to standard of care in patients with chronic kidney disease (CKD) and Type II diabetes (T2D).

The FIDELIO-DKD study is part of the largest phase III studyto date in CKD and T2D. The study enrolled 13,000 patients across a broad range of disease severity, including those with early kidney damage and more advanced stages of kidney disease. The results showed that finerenone delayed the progression of CKD by significantly reducing the combined risk of time to first occurrence of kidney failure, a sustained decrease of estimated glomerular filtration rate (eGFR) greater than or equal to 40% from baseline over a period of at least four weeks, or renal death. Finerenone also reduced the risk of the key secondary endpoints — a composite of time to first occurrence of cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke, or heart failure hospitalization. The clinical data from FIDELIO-DKD will be presented at an upcoming scientific meeting.

Shares of the company have lost 8.9% year to date while the industry did not show any movement.

Finerenone (BAY 94-8862) is an investigational, non-steroidal, selective mineralocorticoid receptor antagonist that has been shown to block the harmful effects of the over-activated mineralocorticoid receptor (MR) system. MR overactivation is a major driver of heart and kidney damage. It is the first non-steroidal MR antagonist being developed in heart failure with preserved ejection fraction.

Last month, the company also initiated a placebo-controlled phase III study, FINEARTS-HF, on finerenone. The study will investigate finerenone compared to placebo in more than 5,500 symptomatic heart failure patients with a left ventricular ejection fraction of ≥40%.

.The primary objective of the study is to demonstrate the superiority of finerenone over placebo in reducing the rate of the composite endpoint of cardiovascular death and total (first and recurrent) heart failure (HF) events. 

Bayer Aktiengesellschaft Price


Bayer Aktiengesellschaft Price

Bayer Aktiengesellschaft price | Bayer Aktiengesellschaft Quote

Zacks Rank and Stocks to Consider

Bayer currently carries a Zacks Rank #2 (Buy).

A few top-ranked stocks worth considering in the large-cap pharma sector include AbbVie Plc (ABBV - Free Report) , Eli Lilly and Company (LLY - Free Report) , and H. Lundbeck A/S (HLUYY - Free Report) .  While AbbVie and Lilly carry a Zacks Rank #1 (Strong Buy), H. Lundbeck carries a Zacks Rank #2 (Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.

AbbVie’s earnings estimates have increased from $9.81 to $10.42 for 2020 and from $11.28 to $12.03 for 2021 over the past 90 days.

Eli Lilly’s earnings estimates have increased from $6.81 to $6.82 for 2020 over the past 60 days.

H. Lundbeck’s earnings estimates have increased from $2.16 to $2.20 for 2020 and from $2.18 to $2.19 for 2021 over the past 60 days.

These Stocks Are Poised to Soar Past the Pandemic

The COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. Right now, investors in these companies have a shot at serious profits. For example, Zoom jumped 108.5% in less than 4 months while most other stocks were sinking. Our research shows that 5 cutting-edge stocks could skyrocket from the exponential increase in demand for “stay at home” technologies. This could be one of the biggest buying opportunities of this decade, especially for those who get in early.

See the 5 high-tech stocks now>>