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Epizyme, Inc.

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Epizyme’s efforts on developing its lead candidate, tazemetostat, for a number of hematological malignancies and genetically defined solid tumors are impressive. Moreover, the company’s efforts on evaluating tazemetostat, in combination with anti-PD 1 or PDL-1 agent, are also encouraging. The company’s collaboration agreement with Celgene for small-molecule HMT inhibitors including pinometostat is a big positive. However, with no approved product in its kitty, Epizyme is highly dependent on its collaboration partners for top-line growth. Moreover, most of its candidates are in early stages of development and hence several years away from commercialization. Epizyme’s share price has outperformed the Zacks classified Medical/Biomedical Genetics industry in the last twelve months. The stock gained 14.8% during this time period compared to the industry’s 11.3% drop.


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