Clovis Oncology ( CLVS Quick Quote CLVS - Free Report) incurred loss of $1.02 per share for the fourth quarter of 2020, wider than the Zacks Consensus Estimate of a loss of 76 cents but narrower than the year-ago loss of $1.81 per share.
Net revenues, entirely from Clovis’ only marketed drug, Rubraca, were up almost 10.2% year over year to $43.3 million in the quarter, slightly beating the Zacks Consensus Estimate of $43.16 million.
Shares of Clovis were down almost 6.1% in pre-market trading, following the dismal earnings performance. The stock has plunged 32.7% in the past year compared with the
industry’s decrease of 11.4%. Quarter in Details
Sales of Rubraca, a PARP inhibitor, in the United States were $36.4 million, compared with $36.1 million in the fourth quarter of 2019. Ex-U.S. market sales were $6.9 million in the fourth quarter compared with $3.2 million in the year-ago quarter.
In the fourth quarter, research & development expenses decreased 21.8% year over year to $56.7 million, primarily due to lower spending on Rubraca clinical studies. Selling, general and administrative expenses declined 9.7% year over year to $40.8 million, driven by cost-saving initiatives and savings due to the COVID-19 situation globally.
Clovis ended the quarter with $240.2 million of cash equivalents and available-for-sale securities compared with $224.7 million as of Sep 30, 2020.
The company expects its cash resources, along with anticipated revenues and available financing sources, to be enough to support its operations in early 2023.
Clovis reported revenues of $164.5 million, up 12.4% year over year. The company’s incurred a loss of $4.38 per share in 2020, 41% narrower than the year-ago period.
Update on Rubraca
In December, Clovis announced that the phase III confirmatory study — ARIEL 4 — evaluating Rubraca met its primary endpoint of improved investigator-assessed progression-free survival. The study was a post-marketing commitment in the United States and Europe
The company has a collaboration with
Bristol-Myers ( BMY Quick Quote BMY - Free Report) to develop Rubraca and pipeline candidate, lucitanib, in combination with the latter’s PD-L1 inhibitor, Opdivo, for several cancer indications. The phase III ATHENA study is evaluating Rubraca plus Opdivo as first-line maintenance treatment in advanced ovarian cancer. Top-line data is expected in the second half of 2021. Interim data from phase II part of LIO-1 study evaluating lucitanib in combination with Opdivo as potential treatment for gynecologic cancers is expected later this year at medical meetings.
A phase II LODESTAR study is evaluating Rubraca in patients with recurrent solid tumors associated with the deleterious homologous recombination repair or HRR gene mutations. Data from the study may be used to file a regulatory application by the end of 2021 or first-half 2022, seeking approval for Rubraca in HRR patients.
The company plans to initiate a phase I/II study in the first half of 2021 to evaluate its peptide-targeted radionuclide therapy and imaging agent candidate, FAP-2286, in multiple tumor types.
Clovis currently has a Zacks Rank #3 (Hold).
Some better-ranked stocks from the drug/biotech sector include
Moderna, Inc. ( MRNA Quick Quote MRNA - Free Report) and Lexicon Pharmaceuticals, Inc. ( LXRX Quick Quote LXRX - Free Report) . While Moderna sports a Zacks Rank #1 (Strong Buy), Lexicon carries a Zacks Rank #2 (Buy). You can see . the complete list of today’s Zacks #1 Rank stocks here
Moderna’s earnings per share estimates have moved up from $9.45 to $14.74 for 2021 in the past 60 days. The stock has soared 757.3% in the past year.
Lexicon’s loss per share estimates narrowed from 66 cents to 17 cents for 2021 in the past 60 days. The company delivered an earnings surprise of 21.72%, on average, in the last four quarters. The stock has risen 170.8% in the past year.
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