Back to top

Image: Bigstock

SpringWorks (SWTX) Begins Dosing in Multiple Myeloma Study

Read MoreHide Full Article

SpringWorks Therapeutics, Inc. (SWTX - Free Report) announced that it has dosed the first patient in a phase Ib study evaluating its investigational gamma secretase inhibitor nirogacestatin combination with teclistamab for the treatment of patients with relapsed/refractory multiple myeloma.

Please note that, teclistamab, an investigational bispecific antibody targeting B-cell maturation antigen (“BCMA”) and CD3, is being developed by Janssen, a wholly owned subsidiary of Johnson and Johnson (JNJ - Free Report) .

The above-mentioned study is part of a multi-arm study being conducted by Janssen. The same will evaluate the safety, tolerability and preliminary efficacy of nirogacestat plus teclistamab in the given patient population.

Shares of SpringWorks have inched up 0.2% so far this year compared with the industry’s increase of 0.5%.

price chart for SWTX


Notably, in September 2020, SpringWorks entered into a collaboration and supply agreement with Janssen, wherein the later agreed to bear all costs related to the phase Ib study, apart from expenses on the supply of nirogacestat.

We remind investors that, in October 2020, SpringWorks entered into a clinical collaboration with Pfizer (PFE - Free Report) to evaluate nirogacestat in combination with the latter’s BCMA-targeted therapy, PF-06863135, for the treatment of patients with relapsed or refractory multiple myeloma.

Also, in August 2020, SpringWorks dosed the first patient in a phase Ib study evaluating nirogacestat in combination with GlaxoSmithKline’s (GSK - Free Report) antibody drug conjugate, Blenrep, for treating patients with relapsed or refractory multiple myeloma.

Meanwhile, SpringWorks is evaluating nirogacestat in a double-blind, placebo-controlled phase III DeFi Trial for treating adult patients with progressing desmoid tumors. The candidate received an Orphan Drug designation from the FDA as well as from the European Commission for the treatment of desmoid tumors and soft tissue sarcoma, respectively.

Zacks Rank

SpringWorks currently carries a Zacks Rank #4 (Sell).You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

Bitcoin, Like the Internet Itself, Could Change Everything

Blockchain and cryptocurrency has sparked one of the most exciting discussion topics of a generation. Some call it the “Internet of Money” and predict it could change the way money works forever. If true, it could do to banks what Netflix did to Blockbuster and Amazon did to Sears. Experts agree we’re still in the early stages of this technology, and as it grows, it will create several investing opportunities.

Zacks’ has just revealed 3 companies that can help investors capitalize on the explosive profit potential of Bitcoin and the other cryptocurrencies with significantly less volatility than buying them directly.

See 3 crypto-related stocks now >>