BioCryst Pharmaceuticals’ ( BCRX Quick Quote BCRX - Free Report) stock was down almost 38% on Friday following its announcement of pausing enrolment in clinical studies for its pipeline candidate, BCX9930
BCX9930 is a BioCryst Pharmaceuticals’ oral Factor D inhibitor being evaluated in several studies for the treatment of complement-mediated diseases. It is in the pivotal development for paroxysmal nocturnal hemoglobinuria (PNH). A proof-of-concept study is also ongoing to evaluate oral BCX9930 (500 mg twice daily) in three renal complement-mediated diseases, C3 glomerulopathy (C3G), IgA nephropathy (IgAN) and primary membranous nephropathy (PMN).
BioCryst Pharmaceuticals said it will not enroll new patients in the REDEEM-1, REDEEM-2 studies for PNH or RENEW clinical studies on BCX9930 as it is investigating rising serum creatinine levels seen in some patients. However, patients already enrolled in these studies are continuing to receive the drug.
Enrolment in the REDEEM-1 and REDEEM-2 studies began in January 2022 and November 2021, respectively. While REDEEM-2 is evaluating the efficacy and safety of BCX9930 (500 mg twice daily) as monotherapy in PNH patients not currently receiving complement inhibitor therapy, REDEEM-1 involves PNH patients with an inadequate response to a C5 inhibitor. The RENEW program is a proof-of-concept basket study evaluating BCX9930 in patients with C3G, IgAN and PMN.
BCX9930 enjoys Orphan Drug and Fast Track designations from the FDA for the treatment of PNH.
This year so far, BioCryst Pharmaceuticals’ shares have declined 19.7% compared with the
industry’s decrease of 12.5%.
Image Source: Zacks Investment Research
BioCryst Pharmaceuticals’ other key pipeline candidates are BCX9250, an ALK-2 inhibitor for the treatment of fibrodysplasia ossificans progressiva, and galidesivir, a potential treatment for Marburg virus disease and Yellow Fever. The company’s hereditary angioedema drug Orladeyo is marketed in the United States, the European Union and some other countries.
Zacks Rank & Stocks to Consider
BioCryst Pharmaceuticals currently carries a Zacks Rank #4 (Sell).
Some better-ranked stocks in the drug sector are
Baudax Bio ( BXRX Quick Quote BXRX - Free Report) , Assertio Holdings ( ASRT Quick Quote ASRT - Free Report) and Collegium Pharmaceutical ( COLL Quick Quote COLL - Free Report) , each carrying a Zacks Rank #1 (Strong Buy). You can see . the complete list of today’s Zacks #1 Rank stocks here
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