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Agios Pharmaceuticals, Inc.

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Agios depends heavily on Celgene for revenues, which it earns in the form of collaboration revenues and royalty revenues on Idhifa sales. Stiff competition from large pharmaceutical companies including AstraZeneca, Bayer, Eli Lilly, Roche, GlaxoSmithKline, Merck, Pfizer and Sanofi is another matter of concern for the company. Shares of the company have underperformed the industry in 2018. Nevertheless, Agios' first wholly owned precision medicine, Tibsovo, was approved by the FDA for treating AML. The drug has generated strong sales in the very first quarter following its FDA nod. The company is also focused on expanding the label for Tibsovo to advance its cancer and rare genetic disease clinical development programs.Loss estimates have widened slighty ahead of the Q4 earnings release. Agios has a mixed record of earnings surprises in recent quarters.

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