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Roche's Tecentriq Combo Study Meets Co-Primary Endpoint

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Roche Holding AG’s (RHHBY - Free Report) subsidiary Genentech announced that a phase III study, evaluating a combination of its PD-L1 inhibitor Tecentriq (atezolizumab) and Avastin (bevacizumab) plus carboplatin and paclitaxel for first line treatment of advanced lung cancer met its co-primary endpoint of overall survival (OS).

The IMpower150 study showed that the patients with advanced non-squamous non-small cell lung cancer (NSCLC) who were treated with the combination treatment lived longer compared with Avastin plus carboplatin and paclitaxel.

The company plans to submit these additional data to global health authorities as well as to the FDA and the European Medicines Agency (EMA) soon.

Over a year, shares of Roche have declined 12.3% against the industry’s growth of 2.8%.

In December 2017, the company had announced interim results from the IMpower 150 study. The IMpower150 study showed that Tecentriq and Avastin plus chemotherapy reduced the risk of disease worsening or death by 38% compared with those who were treated with Avastin plus chemotherapy. In November 2017, Roche mentioned that the III IMpower150 study met its co-primary endpoint of progression-free survival.

Tecentriq is approved for the treatment of second-line metastatic NSCLC. Label expansion in the first line setting should boost the drug’s sales further. Tecentriq is also approved for the treatment of patients suffering from locally advanced or metastatic urothelial carcinoma (mUC) who are not eligible for cisplatin chemotherapy. The drug recorded sales of CHF457 million in 2017.

We remind investors that Merck’s (MRK - Free Report) PD-L1 inhibitor Keytruda is approved by the FDA  both as monotherapy and in combination with Lilly’s  (LLY - Free Report) Alimta and carboplatin for the first line treatment of patients with metastatic nonsquamous NSCLC.

 

Zacks Rank & Other Stock to Consider

Roche carries a Zacks Rank #2 (Buy).

Another top-ranked stock from the same space is Regeneron Pharmaceuticals (REGN - Free Report) ,sporting a Zacks Rank #1 (Strong Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.

Regeneron’s earnings per share estimates have moved up from $18.65 to $18.68 for 2018 in the last 30 days. The company pulled off a positive earnings surprise in three of the last four quarters, with an average beat of 9.15%.

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