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Aduro's Cancer Arm & Strong Collaborations Boost Growth

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On Sep 17, we issued an updated research report on Aduro Biotech, Inc. (ADRO - Free Report) .

Aduro’s three distinct technology platforms, designed to harness the body's natural immune system, are being utilized to develop treatments for several cancer indications and show potential to be expanded into auto-immune and infectious diseases. The three distinct platforms are the live, attenuated, double-deleted (LADD) technology platform, TING pathway activator platform and the B-select monoclonal antibody platform.

So far this year, shares of Aduro have lost 17.4%, wider than the industry’s decrease of 5.9%.


Interesting candidates in the LADD platform include ADU-623 (phase I–glioblastoma), ADU-741 (phase I – metastatic castration resistant prostate cancer) and ADU-214 (phase I – metastatic non-small cell lung cancer). Aduro has a research and license agreement with Janssen, a subsidiary of Johnson & Johnson (JNJ - Free Report) , for developing ADU-214 and ADU-741.

In June, Aduro announced having initiated a phase Ib study of ADU-214 in combination with Bristol-Myers’ (BMY - Free Report) Opdivo (nivolumab) for treating advanced lung cancer. Johnson & Johnson’s affiliate Janssen — Aduro’s license partner for ADU-214 — is conducting this global analysis.

Further, Aduro has a collaboration and license agreement with Novartis (NVS - Free Report) for developing its lead STING Activator candidate ADU-S100. The same is being evaluated in a phase I program as a monotherapy on patients with cutaneously accessible metastatic solid tumors or lymphomas. Top-line data from the program is expected soon.

Aduro is also performing a phase Ib study to assess ADU-S100 in combination with Novartis’ PD-1 checkpoint inhibitor, PDR001, for treating solid tumors and lymphomas.

Aduro’s B-select monoclonal antibody platform has a number of immune modulating assets, currently in research and pre-clinical development stage. Agents from this platform, such as anti-APRIL, anti-CTLA4 and anti-PD1, exhibit promises to generate novel immunotherapy combinations. Last December, Aduro announced to have begun a phase I/II dose escalation program, analyzing its pipeline candidate, BION-1301, for treating adults with relapsed or refractory multiple myeloma.

In August, the United States Patent and Trademark Office granted a new composition of matter patent protecting the BION-1301.

Notably, Aduro’s collaboration agreements with large pharma entities like Novartis (NVS - Free Report) and Johnson & Johnson (JNJ - Free Report) validate the company’s research platforms as well as enhance its financial position, providing it with adequate funds.

It is important to know that Aduro’s portfolio remains devoid of an approved product. Thus, an inability to secure sufficient funding from its collaboration and license agreements could hinder the company’s pipeline progress.

Zacks Rank

Aduro currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

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