We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies, revised Privacy Policy and Terms of Service.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Theravance's Respiratory Disease JAK Inhibitor Enters Phase I
Read MoreHide Full Article
Theravance Biopharma, Inc. (TBPH - Free Report) announced that it has dosed the first patient in a phase I study on its novel, inhaled, lung-selective pan-Janus kinase (JAK) inhibitor, TD-8236. The candidate is currently being developed to evaluate its potential for the treatment of various serious respiratory diseases.
The randomized, placebo-controlled phase I study on TD-8236 consists of two parts. The first will evaluate the candidate in single ascending doses (SAD) on healthy patients with the primary objective of measuring the safety and tolerability. While the second part will evaluate TD-8236 in multiple ascending doses (MAD), also assessing its safety and tolerability in patients with mild, stable asthma.
Notably, in preclinical studies, TD-8236 demonstrated long duration of action in the lung and low plasma levels, indicating that it can be developed as a once-daily treatment with minimal systemic exposure.
Shares of Theravance have lost 9.4% year to date compared with the industry’s decline of 8%.
TD-8236 is particularly designed as a dry-powder inhaler for the lungs with minimal systemic exposure. It is the second JAK inhibitor discovered by Theravance, which has entered a clinical study of late.
Last week, Theravance dosed the first patient in a phase II study on its gut-selective pan-JAK inhibitor, TD-1473, for the treatment of patients with Crohn's disease. TD-1473 is being developed in collaboration with Janssen, a subsidiary of Johnson & Johnson (JNJ - Free Report) , for treating inflammatory intestinal diseases.
Theravance is also evaluating TD-1473 in a phase Ib program for addressing ulcerative colitis. Last month, the company announced data from the exploratory phase Ib study on TD-1473 for treating patients with moderate-to-severe ulcerative colitis.
Another interesting candidate in Theravance’s portfolio is TD-9855, which is currently under inspection for tackling the syndrome of symptomatic neurogenic orthostatic hypotension (nOH). In August, the company announced a positive top-line outcome from the phase II study on the candidate. Additionally, Theravance expects to initiate a registrational phase III study in late 2018 or early 2019.
Theravance currently carries a Zacks Rank #3 (Hold). Two better-ranked stocks in the same sector are BioSpecifics Technologies Corp and Hikma Pharmaceuticals Plc (HKMPF - Free Report) , both sporting a Zacks Rank #1 (Strong Buy).You can see the complete list of today’s Zacks #1 Rank stocks here.
BioSpecifics’ earnings estimates have been revised 9.6% upward for 2018 and 16.8% for 2019 over the past 60 days. The stock has surged 31.6% year to date.
Hikma Pharmaceuticals’ earnings estimates have moved 15% north for 2018 and 10.1% for 2019 over the past 60 days. The stock has soared 59% so far this year.
More Stock News: This Is Bigger than the iPhone!
It could become the mother of all technological revolutions. Apple sold a mere 1 billion iPhones in 10 years but a new breakthrough is expected to generate more than 27 billion devices in just 3 years, creating a $1.7 trillion market.
Zacks has just released a Special Report that spotlights this fast-emerging phenomenon and 6 tickers for taking advantage of it. If you don't buy now, you may kick yourself in 2020.
Image: Bigstock
Theravance's Respiratory Disease JAK Inhibitor Enters Phase I
Theravance Biopharma, Inc. (TBPH - Free Report) announced that it has dosed the first patient in a phase I study on its novel, inhaled, lung-selective pan-Janus kinase (JAK) inhibitor, TD-8236. The candidate is currently being developed to evaluate its potential for the treatment of various serious respiratory diseases.
The randomized, placebo-controlled phase I study on TD-8236 consists of two parts. The first will evaluate the candidate in single ascending doses (SAD) on healthy patients with the primary objective of measuring the safety and tolerability. While the second part will evaluate TD-8236 in multiple ascending doses (MAD), also assessing its safety and tolerability in patients with mild, stable asthma.
Notably, in preclinical studies, TD-8236 demonstrated long duration of action in the lung and low plasma levels, indicating that it can be developed as a once-daily treatment with minimal systemic exposure.
Shares of Theravance have lost 9.4% year to date compared with the industry’s decline of 8%.
TD-8236 is particularly designed as a dry-powder inhaler for the lungs with minimal systemic exposure. It is the second JAK inhibitor discovered by Theravance, which has entered a clinical study of late.
Last week, Theravance dosed the first patient in a phase II study on its gut-selective pan-JAK inhibitor, TD-1473, for the treatment of patients with Crohn's disease. TD-1473 is being developed in collaboration with Janssen, a subsidiary of Johnson & Johnson (JNJ - Free Report) , for treating inflammatory intestinal diseases.
Theravance is also evaluating TD-1473 in a phase Ib program for addressing ulcerative colitis. Last month, the company announced data from the exploratory phase Ib study on TD-1473 for treating patients with moderate-to-severe ulcerative colitis.
Another interesting candidate in Theravance’s portfolio is TD-9855, which is currently under inspection for tackling the syndrome of symptomatic neurogenic orthostatic hypotension (nOH). In August, the company announced a positive top-line outcome from the phase II study on the candidate. Additionally, Theravance expects to initiate a registrational phase III study in late 2018 or early 2019.
Theravance Biopharma, Inc. Price and Consensus
Theravance Biopharma, Inc. Price and Consensus | Theravance Biopharma, Inc. Quote
Zacks Rank & Stocks to Consider
Theravance currently carries a Zacks Rank #3 (Hold). Two better-ranked stocks in the same sector are BioSpecifics Technologies Corp and Hikma Pharmaceuticals Plc (HKMPF - Free Report) , both sporting a Zacks Rank #1 (Strong Buy).You can see the complete list of today’s Zacks #1 Rank stocks here.
BioSpecifics’ earnings estimates have been revised 9.6% upward for 2018 and 16.8% for 2019 over the past 60 days. The stock has surged 31.6% year to date.
Hikma Pharmaceuticals’ earnings estimates have moved 15% north for 2018 and 10.1% for 2019 over the past 60 days. The stock has soared 59% so far this year.
More Stock News: This Is Bigger than the iPhone!
It could become the mother of all technological revolutions. Apple sold a mere 1 billion iPhones in 10 years but a new breakthrough is expected to generate more than 27 billion devices in just 3 years, creating a $1.7 trillion market.
Zacks has just released a Special Report that spotlights this fast-emerging phenomenon and 6 tickers for taking advantage of it. If you don't buy now, you may kick yourself in 2020.
Click here for the 6 trades >>