We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies, revised Privacy Policy and Terms of Service.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Infinity's (INFI) IPI-549 in Focus in a Crowded Cancer Space
Read MoreHide Full Article
Infinity Pharmaceuticals, Inc. is currently focusing on the development of its lead immuno-oncology candidate, IPI-549. It is an orally administered treatment that selectively inhibits phosphoinositide-3 kinase (PI3K)-gamma.
The company is evaluating IPI-549 as a monotherapy and in combination with Bristol-Myers Squibb’s (BMY - Free Report) Opdivo in a phase I/Ib study (MARIO-1) in about 200 patients with advanced solid tumors. The collaboration with Bristol-Myers has provided Infinity a strong partner with expertise in the field of immuno-oncology. Further, it would allow Infinity to expedite the development of IPI-549.
In September, Infinity also initiated two studies on IPI-549. The company initiated a phase II, MARIO-3 study in collaboration with Roche AG (RHHBY - Free Report) , evaluating IPI-549 in combination with Tecentriq and Abraxane (nab-paclitaxel) in front-line triple negative breast cancer (TNBC), and in combination with Tecentriq.
Separately, Arcus Biosciences (RCUS - Free Report) initiated a phase I/Ib study in collaboration with Infinity, evaluating IPI-549 combined with AB298, Arcus's dual adenosine receptor antagonist, and Doxil, a chemotherapy, in patients with advanced TNBC.
Infinity is evaluating IPI-549 for various diseases by partnering with leading pharmaceutical and biotech companies.
Although there has been significant progress in the treatment of cancer, there is a need for additional treatment options. NSCLC, melanoma and SCCHN account for more than 17% of all new cancer cases in the United States. Pre-clinical data demonstrated that IPI-549 may enhance the effects of checkpoint inhibitors and reverse tumor resistance to checkpoint inhibitors by targeting immune cells and altering the immune-suppressive microenvironment, promoting an anti-tumor immune response. As such, IPI-549 represents a potentially complementary approach to restoring anti-tumor immunity in combination with other immunotherapies like checkpoint inhibitors. If successfully developed, approval of IPI-549 will be a huge boost for Infinity.
However, the company has no approved product in its portfolio at the moment, which is a concern. Infinity is likely to face competition in the immuno-oncology arena from companies like AstraZeneca, Celgene, Merck, Novartis, Pfizer, Roche and Eli Lilly, among others.
Wall Street’s Next Amazon
Zacks EVP Kevin Matras believes this familiar stock has only just begun its climb to become one of the greatest investments of all time. It’s a once-in-a-generation opportunity to invest in pure genius.
Image: Bigstock
Infinity's (INFI) IPI-549 in Focus in a Crowded Cancer Space
Infinity Pharmaceuticals, Inc. is currently focusing on the development of its lead immuno-oncology candidate, IPI-549. It is an orally administered treatment that selectively inhibits phosphoinositide-3 kinase (PI3K)-gamma.
The company is evaluating IPI-549 as a monotherapy and in combination with Bristol-Myers Squibb’s (BMY - Free Report) Opdivo in a phase I/Ib study (MARIO-1) in about 200 patients with advanced solid tumors. The collaboration with Bristol-Myers has provided Infinity a strong partner with expertise in the field of immuno-oncology. Further, it would allow Infinity to expedite the development of IPI-549.
In September, Infinity also initiated two studies on IPI-549. The company initiated a phase II, MARIO-3 study in collaboration with Roche AG (RHHBY - Free Report) , evaluating IPI-549 in combination with Tecentriq and Abraxane (nab-paclitaxel) in front-line triple negative breast cancer (TNBC), and in combination with Tecentriq.
Separately, Arcus Biosciences (RCUS - Free Report) initiated a phase I/Ib study in collaboration with Infinity, evaluating IPI-549 combined with AB298, Arcus's dual adenosine receptor antagonist, and Doxil, a chemotherapy, in patients with advanced TNBC.
Infinity is evaluating IPI-549 for various diseases by partnering with leading pharmaceutical and biotech companies.
Although there has been significant progress in the treatment of cancer, there is a need for additional treatment options. NSCLC, melanoma and SCCHN account for more than 17% of all new cancer cases in the United States. Pre-clinical data demonstrated that IPI-549 may enhance the effects of checkpoint inhibitors and reverse tumor resistance to checkpoint inhibitors by targeting immune cells and altering the immune-suppressive microenvironment, promoting an anti-tumor immune response. As such, IPI-549 represents a potentially complementary approach to restoring anti-tumor immunity in combination with other immunotherapies like checkpoint inhibitors. If successfully developed, approval of IPI-549 will be a huge boost for Infinity.
However, the company has no approved product in its portfolio at the moment, which is a concern. Infinity is likely to face competition in the immuno-oncology arena from companies like AstraZeneca, Celgene, Merck, Novartis, Pfizer, Roche and Eli Lilly, among others.
Wall Street’s Next Amazon
Zacks EVP Kevin Matras believes this familiar stock has only just begun its climb to become one of the greatest investments of all time. It’s a once-in-a-generation opportunity to invest in pure genius.
Click for details >>