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Biogen Acquires Early-Stage CNS Drug From Pfizer for $75M
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Biogen Inc. (BIIB - Free Report) announced that it has signed an agreement with Pfizer (PFE - Free Report) to acquire the latter’s CNS-penetrant small molecule inhibitor, PF-05251749. The early-stage candidate has exhibited potential as treatment of behavioral and neurological symptoms across various psychiatric and neurological diseases in early-stage studies.
Per the terms of the agreement, Biogen will pay $75 in upfront payment to Pfizer along with potential additional development and commercialization milestone payments of up to $635 million. Pfizer is also eligible to receive tiered royalties in high-single digits to sub-teens. The transaction is expected to be completed in the first quarter of 2020.
Biogen’s shares have declined 11% in the past year compared with the industry’s decrease of 1.2%
Biogen plans to develop PF-05251749 as potential therapy to treat certain symptoms/disorders of Alzheimer's disease ("AD") and Parkinson's disease ("PD"). It plans to develop PF-05251749 as a treatment for Sundowning symptom in patients with AD and Irregular Sleep Wake Rhythm Disorder (ISWRD) in patients with PD. The company is planning to initiate a phase Ib study in the fourth quarter of 2020.
The acquisition of PF-05251749 is in line with Biogen’s strategic priority to build potential therapies for neurological conditions. Moreover, Biogen regularly in-licenses assets to build its pipeline with several candidates having transformative potential. The company signed collaboration deals with two private biotechs early last year to discover and develop novel treatment options for treating neurological conditions, such as Alzheimer’s disease and Parkinson’s disease.
Biogen has a diversified pipeline with several promising candidates in different stages of clinical development targeting AD and PD.
The company’s aducanumab is a leading candidate for AD. In October last year, Biogen and partner Eisai announced their intention to seek U.S. approval of aducanumab, a few months after it halted two late-stage studies on the same drug, following a futility analysis. Biogen’s decision was based on positive results of a new analysis of larger dataset, which became available after the discontinuation of the studies. The candidate, if approved by the FDA, will become the first medicine to treat Alzheimer’s disease. BAN2401 is another candidate for AD which is currently in late-stage development.
The company is evaluating BIIB054 in a phase II study for treating PD. Important data readouts are expected across clinical programs in multiple sclerosis, epilepsy, Parkinson’s disease and others in 2020.
The drugs presently available just to treat the symptoms of the disease and new treatment options have faced many setbacks and failures. Several large pharma companies, including Biogen, Roche (RHHBY - Free Report) , Amgen (AMGN - Free Report) , Novartis, Merck, Pfizer, Lilly and AstraZeneca stopped development of their AD candidates in 2019/2018 either due to low possibility of success or safety concerns.
Despite the setbacks, companies continue to invest heavily in developing AD treatments, given the high commercial potential in this market. Success in this area means huge returns. This is because more than 5 million Americans are living with AD with the numbers expected to triple by 2050 (Data: Alzheimer's Association). The market has immense commercial potential and companies coming out with new treatments could rake in billions of dollars in sales.
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The biotech sector is projected to surge beyond $775 billion by 2024 as scientists develop treatments for thousands of diseases. They’re also finding ways to edit the human genome to literally erase our vulnerability to these diseases.
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Biogen Acquires Early-Stage CNS Drug From Pfizer for $75M
Biogen Inc. (BIIB - Free Report) announced that it has signed an agreement with Pfizer (PFE - Free Report) to acquire the latter’s CNS-penetrant small molecule inhibitor, PF-05251749. The early-stage candidate has exhibited potential as treatment of behavioral and neurological symptoms across various psychiatric and neurological diseases in early-stage studies.
Per the terms of the agreement, Biogen will pay $75 in upfront payment to Pfizer along with potential additional development and commercialization milestone payments of up to $635 million. Pfizer is also eligible to receive tiered royalties in high-single digits to sub-teens. The transaction is expected to be completed in the first quarter of 2020.
Biogen’s shares have declined 11% in the past year compared with the industry’s decrease of 1.2%
Biogen plans to develop PF-05251749 as potential therapy to treat certain symptoms/disorders of Alzheimer's disease ("AD") and Parkinson's disease ("PD"). It plans to develop PF-05251749 as a treatment for Sundowning symptom in patients with AD and Irregular Sleep Wake Rhythm Disorder (ISWRD) in patients with PD. The company is planning to initiate a phase Ib study in the fourth quarter of 2020.
The acquisition of PF-05251749 is in line with Biogen’s strategic priority to build potential therapies for neurological conditions. Moreover, Biogen regularly in-licenses assets to build its pipeline with several candidates having transformative potential. The company signed collaboration deals with two private biotechs early last year to discover and develop novel treatment options for treating neurological conditions, such as Alzheimer’s disease and Parkinson’s disease.
Biogen has a diversified pipeline with several promising candidates in different stages of clinical development targeting AD and PD.
The company’s aducanumab is a leading candidate for AD. In October last year, Biogen and partner Eisai announced their intention to seek U.S. approval of aducanumab, a few months after it halted two late-stage studies on the same drug, following a futility analysis. Biogen’s decision was based on positive results of a new analysis of larger dataset, which became available after the discontinuation of the studies. The candidate, if approved by the FDA, will become the first medicine to treat Alzheimer’s disease. BAN2401 is another candidate for AD which is currently in late-stage development.
The company is evaluating BIIB054 in a phase II study for treating PD. Important data readouts are expected across clinical programs in multiple sclerosis, epilepsy, Parkinson’s disease and others in 2020.
The drugs presently available just to treat the symptoms of the disease and new treatment options have faced many setbacks and failures. Several large pharma companies, including Biogen, Roche (RHHBY - Free Report) , Amgen (AMGN - Free Report) , Novartis, Merck, Pfizer, Lilly and AstraZeneca stopped development of their AD candidates in 2019/2018 either due to low possibility of success or safety concerns.
Despite the setbacks, companies continue to invest heavily in developing AD treatments, given the high commercial potential in this market. Success in this area means huge returns. This is because more than 5 million Americans are living with AD with the numbers expected to triple by 2050 (Data: Alzheimer's Association). The market has immense commercial potential and companies coming out with new treatments could rake in billions of dollars in sales.
Biogen Inc. Price
Biogen Inc. price | Biogen Inc. Quote
Zacks Rank
Biogen currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
Breakout Biotech Stocks with Triple-Digit Profit Potential
The biotech sector is projected to surge beyond $775 billion by 2024 as scientists develop treatments for thousands of diseases. They’re also finding ways to edit the human genome to literally erase our vulnerability to these diseases.
Zacks has just released Century of Biology: 7 Biotech Stocks to Buy Right Now to help investors profit from 7 stocks poised for outperformance. Our recent biotech recommendations have produced gains of +50%, +83% and +164% in as little as 2 months. The stocks in this report could perform even better.
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