Back to top

Analyst Blog

Zacks Equity Research

MEIP Starts Phase II Study on Pracinostat


 ZacksTrade Now

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at or call 800-767-3771 ext.  9339.

MEI Pharma, Inc. (MEIP - Snapshot Report) recently commenced a phase II study of Pracinostat in combination with Vidaza (azacitidine) for the treatment of myelodysplastic syndrome (MDS).

The multicenter, randomized, placebo-controlled phase II study is being performed in patients with previously untreated intermediate-2 or high-risk MDS to evaluate the safety and efficacy of Pracinostat compared to placebo when combined with Vidaza.

MEI Pharma expects to complete patient enrollment in this study in Jun 2014, with top-line data expected in Dec 2014.

The primary endpoint of this study is the achievement of complete remission (CR), while secondary endpoints include overall response rate, hematologic improvement, duration of response, progression free survival (PFS), rate of leukemic transformation, overall survival (OS) and safety.

MEI Pharma will start two open-label phase II studies of Pracinostat around Sep 2013: one in combination with Vidaza in frontline acute myeloid leukemia (AML) and the other in combination with Vidaza or Astex Pharmaceuticals, Inc. / Eisai Co., Ltd.’ s / (ESALY) Dacogen in patients with refractory MDS.

In Dec 2012, MEI Pharma had presented results from a study on Pracinostat plus Vidaza in patients with intermediate-2 or high-risk MDS. The study showed an overall response rate of 89%.

Many candidates are being developed for the treatment of MDS, like Astex’s SGI-110, to treat patients with intermediate or high risk relapsed or refractory MDS. Another candidate, Telintra, is being developed for MDS.

MEI Pharma currently carries a Zacks Rank #3 (Hold). Right now, Santarus, Inc. looks more attractive in the pharma space with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
DIXIE GROUP DXYN 15.84 +7.90%
BOFL HOLDING BOFI 85.30 +4.97%
RAMBUS INC RMBS 12.31 +4.41%
VIPSHOP HOLD VIPS 148.73 +4.35%
NETFLIX INC NFLX 345.74 +4.32%