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Aeglea Initiates Lung Cancer Combination Study With Keytruda
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Aeglea BioTherapeutics, Inc. announced that it has initiated dosing of patients in two studies evaluating its lung cancer candidate, pegzilarginase, in small cell lung cancer (“SCLC”).
A cohort expansion phase I study is evaluating pegzilarginase as monotherapy in SCLC patients. The other one is phase I/II study evaluating the candidate in combination with Merck’s (MRK - Free Report) anti-PD-1 therapy, Keytruda, in a similar indication.
Top-line data from the studies are expected in the fourth quarter of 2018.
Aeglea’s shares have risen 77.8% so far this year, against the industry’s loss of 4.9% during the period.
The SCLC expansion cohort is one of the three arms of the phase I study, which is evaluating pegzilarginase in cancer tumors that stop producing a certain amino acid, arginine. Depletion in arginine levels in the tumors causes cell death and promotes anti-tumor immune responses.
The phase I/II study is evaluating combination of pegzilarginase and Keytruda for overall response rate in patients with extensive disease SCLC whose disease has relapsed or progressed after receiving platinum-based chemotherapy.
Per the press release, only 6% of SCLC patients survive after five years of treatment, showing a significant unmet need.
Several pharma companies are developing therapies for treating SCLC. AstraZeneca (AZN - Free Report) is developing a combination of its PARP inhibitor, Lynparza, and chemotherapy, Temodar, in a phase I/II study. AbbVie (ABBV - Free Report) and Bristol-Myers have collaborated to develop rovalpituzumab tesirine in combination with Opdivo and Yervoy in a phase I study. G1 Therapeutics is also developing therapies in combination with chemotherapy for SCLC.
Apart from SCLC, Aeglea is also developing pegzilarginase in a phase I/II study in patients with Arginase 1 deficiency, a rare genetic disease. The company reported positive preliminary data from the study earlier this month.
Last year, it generated $8 billion in global revenues. By 2020, it's predicted to blast through the roof to $47 billion. Famed investor Mark Cuban says it will produce "the world's first trillionaires," but that should still leave plenty of money for regular investors who make the right trades early.
Image: Bigstock
Aeglea Initiates Lung Cancer Combination Study With Keytruda
Aeglea BioTherapeutics, Inc. announced that it has initiated dosing of patients in two studies evaluating its lung cancer candidate, pegzilarginase, in small cell lung cancer (“SCLC”).
A cohort expansion phase I study is evaluating pegzilarginase as monotherapy in SCLC patients. The other one is phase I/II study evaluating the candidate in combination with Merck’s (MRK - Free Report) anti-PD-1 therapy, Keytruda, in a similar indication.
Top-line data from the studies are expected in the fourth quarter of 2018.
Aeglea’s shares have risen 77.8% so far this year, against the industry’s loss of 4.9% during the period.
The SCLC expansion cohort is one of the three arms of the phase I study, which is evaluating pegzilarginase in cancer tumors that stop producing a certain amino acid, arginine. Depletion in arginine levels in the tumors causes cell death and promotes anti-tumor immune responses.
The phase I/II study is evaluating combination of pegzilarginase and Keytruda for overall response rate in patients with extensive disease SCLC whose disease has relapsed or progressed after receiving platinum-based chemotherapy.
Per the press release, only 6% of SCLC patients survive after five years of treatment, showing a significant unmet need.
Several pharma companies are developing therapies for treating SCLC. AstraZeneca (AZN - Free Report) is developing a combination of its PARP inhibitor, Lynparza, and chemotherapy, Temodar, in a phase I/II study. AbbVie (ABBV - Free Report) and Bristol-Myers have collaborated to develop rovalpituzumab tesirine in combination with Opdivo and Yervoy in a phase I study. G1 Therapeutics is also developing therapies in combination with chemotherapy for SCLC.
Apart from SCLC, Aeglea is also developing pegzilarginase in a phase I/II study in patients with Arginase 1 deficiency, a rare genetic disease. The company reported positive preliminary data from the study earlier this month.
Aeglea BioTherapeutics, Inc. Price
Aeglea BioTherapeutics, Inc. Price | Aeglea BioTherapeutics, Inc. Quote
Zacks Rank
Aeglea currently has a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
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