Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at support@zacks.com or call 800-767-3771 ext.  9339.

UCB (UCBJF) and Amgen Inc. (AMGN - Analyst Report) recently announced their decision to discontinue a phase III program being conducted with CDP7851/AMG785 (romosozumab) for the acceleration of fracture healing. UCB/Amgen’s decision was based on phase II data and regulatory guidance on fracture healing programs. Full phase II results will be presented shortly.

The companies pointed out that the safety profile was not an issue where the decision to discontinue the program was concerned.

However, UCB and Amgen said that they will continue studying CDP7851/AMG785 for the treatment of postmenopausal osteoporosis (PMO).

In Apr 2011, Amgen and UCB had announced positive phase II top-line results on CDP7851/AMG785. The phase II study compared CDP7851/AMG785 to placebo in postmenopausal women with low bone mineral density (BMD) for the treatment of PMO.

CDP7851/AMG785 met its primary endpoint and showed a significant increase in lumbar spine BMD at month 12 compared to placebo.

A phase III program for CDP7851/AMG785 is currently under progress for the treatment of PMO.

The program will evaluate approximately 10,000 PMO patients in two pivotal phase III studies. The first study is placebo controlled and will evaluate the incidence of new vertebral fractures at 12 and 24 months in 6,000 patients. The second is an active controlled study versus alendronate that will evaluate the occurrence of clinical fracture and new vertebral fracture at 12 and 24 months in 4,000 patients. Results from the phase III program should start coming out by the end of 2015.

We expect investor focus to remain on CDP7851/AMG785 for the treatment of PMO. Both UCB and Amgen carry a Zacks Rank #3 (Hold). Right now, Targacept, Inc. (TRGT - Snapshot Report) and Salix Pharmaceuticals Ltd. (SLXP - Analyst Report) look more attractive with a Zacks Rank #1 (Strong Buy).

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
LAKE SHORE G LSG 0.77 +6.05%
QUESTCOR PHA QCOR 80.07 +2.47%
VIPSHOP HOLD VIPS 156.35 +1.82%
ENLINK MIDST ENLC 36.29 +1.60%
BNC BANCORP BNCN 17.33 +1.58%