We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies, revised Privacy Policy and Terms of Service.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Prothena (PRTA) Q1 Loss Wider Than Expected, Pipeline in Focus
Read MoreHide Full Article
Clinical-stage company, Prothena Corporation (PRTA - Free Report) , reported a loss of 91 cents per share, wider than the Zacks Consensus Estimate of a loss of 80 cents and the year-ago quarter’s loss of 59 cents.
Revenues mainly came from the company’s collaboration with Roche Holdings (RHHBY - Free Report) . Quarterly revenues came in at $160,000, missing the Zacks Consensus Estimate by 3.03%. Revenues were up from $141,000 in the year-ago quarter.
The company’s shares have surged 91.3% in the year so far against the industry’s decline of 6.5%.
Quarter in Detail
R&D expenses were $21.1 million, up from $15.2 million in the year-ago quarter, primarily due to higher R&D consulting expenses, increased personnel expenses and elevated manufacturing expenses primarily related to the PRX012 and birtamimab programs.
General and administrative (G&A) expenses came in at $11.1 million, up from $9.7 million in the year-ago quarter, primarily due to higher personnel expenses and increased expenses for the directors’ and officers’ insurance premium.
As of Mar 31, 2021, Prothena had $3457.7 million in cash, cash equivalents and restricted cash, and no debt.
Pipeline Updates
The company is evaluating prasinezumab in collaboration with Roche for the treatment of Parkinson’s disease. Prothena earned a $60-million milestone with the first patient dosed in the PADOVA study in the second quarter.
Prothena announced plans in February 2021 to advance birtamimab, a potential treatment for AL amyloidosis, to the confirmatory phase III AFFIRM-AL study in Mayo Stage IV patients with AL amyloidosis. The decision was based on the significant survival benefit favoring birtamimab, from the previous VITAL study in a subset of patients categorized as Mayo Stage IV at baseline and multiple in-depth discussions with the FDA.
Prothena reported encouraging results from the phase I study of PRX004, a potential treatment for ATTR amyloidosis.
Meanwhile, the company is advancing an early-stage pipeline of programs for a number of potential neurological indications with Bristol-Myers Squibb (BMY - Free Report) . PRX005, a potential treatment for Alzheimer’s disease (AD), is an investigational antibody that targets tau, a protein implicated in diseases including AD, frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), chronic traumatic encephalopathy (CTE) and other tauopathies.
PRX005 demonstrated significant inhibition of cell-to-cell transmission and neuronal internalization in vitro and in vivo, and slowed pathological progression in a tau transgenic mouse model. An Investigational New Drug Application (IND) is expected by the third quarter of 2021.
Prothena Corporation plc Price, Consensus and EPS Surprise
Repligen’s earnings estimates have increased 25 cents for 2021 in the past 90 days.
Zacks Top 10 Stocks for 2021
In addition to the stocks discussed above, would you like to know about our 10 best buy-and-hold tickers for the entirety of 2021?
Last year's 2020 Zacks Top 10 Stocks portfolio returned gains as high as +386.8%. Now a brand-new portfolio has been handpicked from over 4,000 companies covered by the Zacks Rank. Don’t miss your chance to get in on these long-term buys.
Image: Bigstock
Prothena (PRTA) Q1 Loss Wider Than Expected, Pipeline in Focus
Clinical-stage company, Prothena Corporation (PRTA - Free Report) , reported a loss of 91 cents per share, wider than the Zacks Consensus Estimate of a loss of 80 cents and the year-ago quarter’s loss of 59 cents.
Revenues mainly came from the company’s collaboration with Roche Holdings (RHHBY - Free Report) . Quarterly revenues came in at $160,000, missing the Zacks Consensus Estimate by 3.03%. Revenues were up from $141,000 in the year-ago quarter.
The company’s shares have surged 91.3% in the year so far against the industry’s decline of 6.5%.
Quarter in Detail
R&D expenses were $21.1 million, up from $15.2 million in the year-ago quarter, primarily due to higher R&D consulting expenses, increased personnel expenses and elevated manufacturing expenses primarily related to the PRX012 and birtamimab programs.
General and administrative (G&A) expenses came in at $11.1 million, up from $9.7 million in the year-ago quarter, primarily due to higher personnel expenses and increased expenses for the directors’ and officers’ insurance premium.
As of Mar 31, 2021, Prothena had $3457.7 million in cash, cash equivalents and restricted cash, and no debt.
Pipeline Updates
The company is evaluating prasinezumab in collaboration with Roche for the treatment of Parkinson’s disease. Prothena earned a $60-million milestone with the first patient dosed in the PADOVA study in the second quarter.
Prothena announced plans in February 2021 to advance birtamimab, a potential treatment for AL amyloidosis, to the confirmatory phase III AFFIRM-AL study in Mayo Stage IV patients with AL amyloidosis. The decision was based on the significant survival benefit favoring birtamimab, from the previous VITAL study in a subset of patients categorized as Mayo Stage IV at baseline and multiple in-depth discussions with the FDA.
Prothena reported encouraging results from the phase I study of PRX004, a potential treatment for ATTR amyloidosis.
Meanwhile, the company is advancing an early-stage pipeline of programs for a number of potential neurological indications with Bristol-Myers Squibb (BMY - Free Report) . PRX005, a potential treatment for Alzheimer’s disease (AD), is an investigational antibody that targets tau, a protein implicated in diseases including AD, frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), chronic traumatic encephalopathy (CTE) and other tauopathies.
PRX005 demonstrated significant inhibition of cell-to-cell transmission and neuronal internalization in vitro and in vivo, and slowed pathological progression in a tau transgenic mouse model. An Investigational New Drug Application (IND) is expected by the third quarter of 2021.
Prothena Corporation plc Price, Consensus and EPS Surprise
Prothena Corporation plc price-consensus-eps-surprise-chart | Prothena Corporation plc Quote
Zacks Rank & Stock to Consider
Prothena currently carries a Zacks Rank #3 (Hold). A better-ranked stock in the healthcare sector includes Repligen Corp. (RGEN - Free Report) , which carries a Zacks Rank #2 (Buy). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
Repligen’s earnings estimates have increased 25 cents for 2021 in the past 90 days.
Zacks Top 10 Stocks for 2021
In addition to the stocks discussed above, would you like to know about our 10 best buy-and-hold tickers for the entirety of 2021?
Last year's 2020 Zacks Top 10 Stocks portfolio returned gains as high as +386.8%. Now a brand-new portfolio has been handpicked from over 4,000 companies covered by the Zacks Rank. Don’t miss your chance to get in on these long-term buys.
Access Zacks Top 10 Stocks for 2021 today >>