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Alnylam (ALNY) Q2 Earnings: Taking a Look at Key Metrics Versus Estimates

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For the quarter ended June 2025, Alnylam Pharmaceuticals (ALNY - Free Report) reported revenue of $773.69 million, up 17.3% over the same period last year. EPS came in at $0.32, compared to $0.56 in the year-ago quarter.

The reported revenue represents a surprise of +14.96% over the Zacks Consensus Estimate of $673 million. With the consensus EPS estimate being -$0.03, the EPS surprise was +1166.67%.

While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall Street expectations to determine their next move, some key metrics always offer a more accurate picture of a company's financial health.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Alnylam performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenues- Product revenues, net: $672.21 million versus the 11-analyst average estimate of $540.14 million. The reported number represents a year-over-year change of +63.9%.
  • Revenues- Royalty revenue: $39.98 million versus the nine-analyst average estimate of $32.74 million. The reported number represents a year-over-year change of +78.5%.
  • Net Product Revenue- Oxlumo: $46.87 million versus $46.64 million estimated by nine analysts on average. Compared to the year-ago quarter, this number represents a +15.4% change.
  • Revenues- Net revenues from research collaborators: $61.5 million versus $90.07 million estimated by nine analysts on average. Compared to the year-ago quarter, this number represents a -73% change.
  • Net Product Revenue- Givlaari: $80.85 million compared to the $72.59 million average estimate based on nine analysts. The reported number represents a change of +30.1% year over year.
  • Net Product Revenue- Amvuttra: $491.95 million versus $365.41 million estimated by eight analysts on average. Compared to the year-ago quarter, this number represents a +113.8% change.
  • Net Product Revenue- Onpattro: $52.24 million compared to the $45.89 million average estimate based on eight analysts. The reported number represents a change of -32.4% year over year.
  • Net revenues from research collaborators- Other: $10.69 million versus $3 million estimated by two analysts on average. Compared to the year-ago quarter, this number represents a +872.4% change.
  • Net revenues from research collaborators- Regeneron Pharmaceuticals: $32.54 million versus $17.5 million estimated by two analysts on average. Compared to the year-ago quarter, this number represents a -84.3% change.
  • Net revenues from research collaborators- Roche: $18.27 million compared to the $12 million average estimate based on two analysts. The reported number represents a change of +10.7% year over year.

View all Key Company Metrics for Alnylam here>>>

Shares of Alnylam have returned +3% over the past month versus the Zacks S&P 500 composite's +2.7% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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