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Ionis Pharmaceuticals (IONS) Reports Q3 Earnings: What Key Metrics Have to Say

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Ionis Pharmaceuticals (IONS - Free Report) reported $243 million in revenue for the quarter ended September 2026, representing a year-over-year increase of 54.8%. EPS of -$0.40 for the same period compares to -$0.61 a year ago.

The reported revenue represents a surprise of +35.81% over the Zacks Consensus Estimate of $178.93 million. With the consensus EPS estimate being -$1.00, the EPS surprise was +60%.

While investors closely watch year-over-year changes in headline numbers -- revenue and earnings -- and how they compare to Wall Street expectations to determine their next course of action, some key metrics always provide a better insight into a company's underlying performance.

Since these metrics play a crucial role in driving the top- and bottom-line numbers, comparing them with the year-ago numbers and what analysts estimated about them helps investors better project a stock's price performance.

Here is how Ionis Pharmaceuticals performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenue- Total commercial revenue: $136 million versus the eight-analyst average estimate of $140.09 million. The reported number represents a year-over-year change of +17.2%.
  • Revenue- Product sales, net: $48 million versus the eight-analyst average estimate of $56.46 million. The reported number represents a year-over-year change of +50%.
  • Revenue- Total research and development revenue: $107 million versus the eight-analyst average estimate of $38.84 million. The reported number represents a year-over-year change of +161%.
  • Revenue- Royalty revenue- SPINRAZA royalties: $69 million versus the seven-analyst average estimate of $55.98 million. The reported number represents a year-over-year change of +23.2%.
  • Revenue- Commercial revenue- Other commercial revenue: $7 million versus the seven-analyst average estimate of $5.16 million. The reported number represents a year-over-year change of -12.5%.
  • Revenue- Royalty revenue- WAINUA royalties: $7 million compared to the $17.67 million average estimate based on seven analysts.
  • Revenue- Royalty revenue: $81 million compared to the $78.28 million average estimate based on seven analysts.
  • Revenue- Product sales net- DAWNZERA sales: $37 million versus $33.15 million estimated by seven analysts on average.
  • Revenue- Product sales net- TRYNGOLZA sales: $9 million compared to the $23.09 million average estimate based on seven analysts.
  • Revenue- Royalty revenue- Other royalties: $5 million compared to the $3.96 million average estimate based on six analysts. The reported number represents a change of -28.6% year over year.
  • Revenue- Research and development revenue- WAINUA joint development revenue: $4 million compared to the $13.7 million average estimate based on five analysts.
  • Revenue- Research and development revenue- Collaborative agreement revenue: $103 million compared to the $19 million average estimate based on five analysts. The reported number represents a change of +232.3% year over year.

View all Key Company Metrics for Ionis Pharmaceuticals here>>>

Shares of Ionis Pharmaceuticals have returned -12.9% over the past month versus the Zacks S&P 500 composite's -5.6% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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