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Novartis (NVS) Announces Positive Data From Cosentyx Study
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Novartis AG (NVS - Free Report) announced the full-52 week data from the ongoing PREVENT study on spondylitis drug, Cosentyx (secukinumab). The new, detailed data from the study reinforced the drug’s substantial and sustained benefits across axial spondyloarthritis (axSpA) spectrum.
Data from the study showed that treatment with 150mg dose of Cosentyx achieved significant and sustained improvements in signs and symptoms of non-radiographic axial spondyloarthritis (nr-axSpA) at 52 weeks. Treatment with Cosentyx improved signs and symptoms of nr-axSpA in patients by 40% as measured by Assessment of Spondyloarthritis International Society score, compared to placebo at week 16 and week 52. The company had announced late last year that the drug met the primary endpoint of the PREVENT study.
PREVENT is an ongoing two-year randomized, double-blind, placebo-controlled phase III study (with a two-year extension phase) investigating the efficacy and safety of Cosentyx in patients with active nr-axSpA.
Notably, axial spondyloarthritis (axSpA) is a spectrum of long-term inflammatory disease characterized by chronic inflammatory back pain. nr-axSpA forms part of the axSpA spectrum and is characterized by chronic inflammatory back pain and symptoms such as nocturnal pain, morning stiffness and impaired quality of life. The spectrum includes ankylosing spondylitis (AS), in which joint damage is visible on x-ray, and nr-axSpA, in which joint damage is not visible on x-ray.
Per estimates, approximately 1.7 million patients with nr-axSpA are living in the European Union and the United States.
Please note that Cosentyx was approved in Europe as a treatment for nr-axSpA in April. Novartis has also submitted a regulatory application to the FDA seeking approval for the drug in the same indication. Data from the PREVENT study can support a potential approval. Launch of the drug in the U.S. and European markets will likely boost its sales on the back of a significant patient population.
However, there are several other drugs available for treating axSpA including Lilly’s (LLY - Free Report) Taltz, which received approval for a label expansion to include nr-axSpA patients earlier this week.
Novartis’ shares have lost 1.7% in the year so far compared with the industry’s decline of 2.8%.
Cosentyx is the first and only fully-human biologic that directly inhibits interleukin-17A (IL-17A). The drug is already approved for treating plaque psoriasis, psoriatic arthritis and ankylosing spondylitis. Sales of the drug came in at $930 million in the first quarter of 2020, representing a year over year growth of 19%.
However, the drug faces stiff competition from the likes of Johnson & Johnson's (JNJ - Free Report) Stelara and Tremfya, and AbbVie’s (ABBV - Free Report) Skyrizi in various indications.
The COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. Right now, investors in these companies have a shot at serious profits. For example, Zoom jumped 108.5% in less than 4 months while most other stocks were sinking.
Our research shows that 5 cutting-edge stocks could skyrocket from the exponential increase in demand for “stay at home” technologies. This could be one of the biggest buying opportunities of this decade, especially for those who get in early.
Image: Bigstock
Novartis (NVS) Announces Positive Data From Cosentyx Study
Novartis AG (NVS - Free Report) announced the full-52 week data from the ongoing PREVENT study on spondylitis drug, Cosentyx (secukinumab). The new, detailed data from the study reinforced the drug’s substantial and sustained benefits across axial spondyloarthritis (axSpA) spectrum.
Data from the study showed that treatment with 150mg dose of Cosentyx achieved significant and sustained improvements in signs and symptoms of non-radiographic axial spondyloarthritis (nr-axSpA) at 52 weeks. Treatment with Cosentyx improved signs and symptoms of nr-axSpA in patients by 40% as measured by Assessment of Spondyloarthritis International Society score, compared to placebo at week 16 and week 52. The company had announced late last year that the drug met the primary endpoint of the PREVENT study.
PREVENT is an ongoing two-year randomized, double-blind, placebo-controlled phase III study (with a two-year extension phase) investigating the efficacy and safety of Cosentyx in patients with active nr-axSpA.
Notably, axial spondyloarthritis (axSpA) is a spectrum of long-term inflammatory disease characterized by chronic inflammatory back pain. nr-axSpA forms part of the axSpA spectrum and is characterized by chronic inflammatory back pain and symptoms such as nocturnal pain, morning stiffness and impaired quality of life. The spectrum includes ankylosing spondylitis (AS), in which joint damage is visible on x-ray, and nr-axSpA, in which joint damage is not visible on x-ray.
Per estimates, approximately 1.7 million patients with nr-axSpA are living in the European Union and the United States.
Please note that Cosentyx was approved in Europe as a treatment for nr-axSpA in April. Novartis has also submitted a regulatory application to the FDA seeking approval for the drug in the same indication. Data from the PREVENT study can support a potential approval. Launch of the drug in the U.S. and European markets will likely boost its sales on the back of a significant patient population.
However, there are several other drugs available for treating axSpA including Lilly’s (LLY - Free Report) Taltz, which received approval for a label expansion to include nr-axSpA patients earlier this week.
Novartis’ shares have lost 1.7% in the year so far compared with the industry’s decline of 2.8%.
Cosentyx is the first and only fully-human biologic that directly inhibits interleukin-17A (IL-17A). The drug is already approved for treating plaque psoriasis, psoriatic arthritis and ankylosing spondylitis. Sales of the drug came in at $930 million in the first quarter of 2020, representing a year over year growth of 19%.
However, the drug faces stiff competition from the likes of Johnson & Johnson's (JNJ - Free Report) Stelara and Tremfya, and AbbVie’s (ABBV - Free Report) Skyrizi in various indications.
Novartis AG Price
Novartis AG price | Novartis AG Quote
Zacks Rank
Novartis currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
These Stocks Are Poised to Soar Past the Pandemic
The COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. Right now, investors in these companies have a shot at serious profits. For example, Zoom jumped 108.5% in less than 4 months while most other stocks were sinking.
Our research shows that 5 cutting-edge stocks could skyrocket from the exponential increase in demand for “stay at home” technologies. This could be one of the biggest buying opportunities of this decade, especially for those who get in early.
See the 5 high-tech stocks now>>