Back to top

Analyst Blog

Janssen Biotech, Inc., a Johnson & Johnson (JNJ - Analyst Report) company, will be moving oncology candidate, daratumumab, into a new phase II study for multiple myeloma shortly. Janssen’s partner, Genmab (GNMSF) announced that the new study will be conducted in multiple myeloma patients who have undergone at least three different lines of treatment including a proteasome inhibitor like Velcade (bortezomib) or Kyprolis (carfilzomib) as well as an immunomodulatory agent (IMiD) like Pomalyst (pomalidomide) or Revlimid (lenalidomide) or double refractory multiple myeloma patients.

The study will be conducted in two parts – Part 1 will determine the optimal regimen for daratumumab. Once initial data from Part 1 is out, the study will be expanded into Part 2. The study will basically determine the optimal dose and dosing schedule. Moreover, Genmab said that daratumumab’s efficacy (overall response rate) and safety as a monotherapy will be evaluated.

We note that daratumumab was granted Breakthrough Therapy Designation by the FDA in May 2013 for this indication. In addition to being developed for multiple myeloma, daratumumab has the potential to be evaluated for other cancers like diffuse large B-cell lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, plasma cell leukemia, acute myeloid leukemia, follicular lymphoma and mantle cell lymphoma.

Daratumumab is being developed under a collaboration agreement between Janssen and Genmab that was signed in Aug 2012. Janssen has the exclusive global right to develop and commercialize daratumumab.

While Genmab is currently a Zacks Rank #4 (Sell) stock, Johnson & Johnson holds a Zacks Rank #3 (Hold). Johnson & Johnson’s target of filing for approval of more than 10 new products and more than 25 line extensions by 2017 should help lessen the impact of the genericization of key products in the pharma portfolio.

At present, large-cap pharma companies like Bayer (BAYRY - Analyst Report) and Novo Nordisk (NVO - Analyst Report) look well-positioned with both being Zacks Rank #2 (Buy) stocks.
 

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
PLANAR SYST… PLNR 4.35 +4.82%
CENTURY ALU… CENX 22.50 +4.36%
ERBA DIAGNO… ERB 2.90 +3.94%
MALLINCKROD… MNK 71.96 +3.52%
GTT COMMUNI… GTT 12.04 +3.35%