Back to top

Analyst Blog

Amgen’s (AMGN - Analyst Report) romosozumab (AMG 785/CDP7851) is one of the most promising and interesting candidates in the company’s pipeline. Romosozumab works by inhibiting the protein sclerostin, thereby leading to an increase in bone formation and decrease in bone breakdown in women post-menopause.

Amgen is developing romosozumab for the treatment of low bone mineral density (BMD) in collaboration with UCB.

Amgen and UCB recently released positive data on romosozumab from a multicenter randomized placebo-controlled phase II trial (n=419). The data was published in the New England Journal of Medicine. The data from the trial showed that romosozumab increased BMD at the lumbar spine, total hip and femoral neck region after 12 months of treatment as compared to placebo.

In addition, treatment with romosozumab resulted in greater increases in bone mineral density when compared to current treatments like Merck & Co, Inc.’s (MRK - Analyst Report) Fosamax and Eli Lilly’s (LLY - Analyst Report) Forteo.

Meanwhile, a phase III program for romosozumab is currently under progress for the treatment of BMD post menopause.

The program will evaluate approximately 10,000 postmenopausal osteoporosis patients in two pivotal phase III studies.

We remind investors that UCB and Amgen discontinued their development program on romosozumab for the acceleration of fracture healing in 2013. UCB/Amgen’s decision was based on phase II data and regulatory guidance on fracture healing programs. The safety profile was not an issue where the decision to discontinue the program was concerned.

Amgen carries a Zacks Rank #3 (Hold). At current levels, Isis Pharmaceuticals (ISIS - Analyst Report) looks attractive with a Zacks Rank #2 (Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
UTD THERAPE… UTHR 117.83 +28.51%
TRIQUINT SE… TQNT 20.67 +6.52%
RF MICRO DE… RFMD 12.47 +6.04%
VASCO DATA… VDSI 14.77 +4.68%
BANCO DO BR… BDORY 15.53 +3.95%