Back to top

Analyst Blog

This page is temporarily not available.  Please check later as it should be available shortly. If you have any questions, please email customer support at or call 800-767-3771 ext.  9339.

Isis Pharmaceuticals, Inc. (ISIS - Analyst Report) recently commenced a phase II study with its spinal muscular atrophy (SMA) candidate, ISIS-SMNRx.

The open-label, multiple-dose, dose-escalation pilot phase II study will be performed in eight infants for the treatment of SMA.

With the enrollment of the first patient which is expected in May 2013, Isis Pharma will become eligible to receive a $3.5 million milestone payment from partner, Biogen Idec Inc. (BIIB - Analyst Report).

In Mar 2013, data from an open-label phase I study evaluating ISIS-SMNRx in children with SMA was presented. Results showed that ISIS-SMNRx was well tolerated at all dose levels tested. Additionally, improvements in Hammersmith scores were also observed.

Moreover, in Nov 2012, Isis Pharma started phase a Ib/IIa study to evaluate ISIS-SMNRx in children with SMA. The information from this study will aid in finding the dose for the phase II/III registration-directed study in children with SMA.

According to information provided by Isis Pharma, around 30,000-35,000 patients in the US, Europe and Japan suffer from SMA. According to The SMA Trust, one child out of every 6,000 births is affected by SMA. 

Repligen Corp. (RGEN) is developing RG3039 for the treatment of SMA. It has also entered into a licensing agreement for the advancement of its SMA program. RG3039 is in phase I trial – the first two arms of this trial will be completed by Repligen.

Isis Pharma and Biogen Idec carry a Zacks Rank #3 (Hold). Right now, Cleveland BioLabs, Inc. (CBLI - Snapshot Report) looks more attractive with a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

Learn more

Start for as little as $4.50 per trade.

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
DIXIE GRP IN DXYN 15.84 +7.90%
BOFI HLDG IN BOFI 85.30 +4.97%
RAMBUS INC RMBS 12.31 +4.41%
VIPSHOP HOLD VIPS 148.73 +4.35%
NETFLIX INC NFLX 345.74 +4.32%