We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. By pressing "Accept All" or closing out of this banner, you accept our Privacy Policy and Terms of Service, revised from time to time, and you consent to the use of all cookies and similar technologies and the sharing of information they collect with third parties. You can reject marketing cookies by pressing "Deny Optional," but we still use essential, performance, and functional cookies.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Athira (ATHA) Completes Dosing in Alzheimer's Study, Stock Up
Read MoreHide Full Article
Athira Pharma, Inc (ATHA - Free Report) recently announced that it has dosed the last patient in the phase II/III LIFT-AD study, which is evaluating its pipeline candidate, fosgonimeton for the treatment of mild-to-moderate Alzheimer’s disease (AD). Shares of the company were up 29.4%, following the announcement of the news.
The LIFT-AD study evaluates once-daily fosgonimeton (40 mg) subcutaneous injection versus placebo over a treatment period of 26 weeks in mild-to-moderate AD patients. The study is designed to assess the treatment effects of fosgonimeton across multiple aspects of AD.
The primary endpoint of the LIFT-AD study is to see the change from baseline following 26 weeks of treatment using the Global Statistical Test, which evaluates cognition and function, the two key measures of disease progression.
Other secondary and exploratory endpoints are changes in plasma biomarkers of neurodegeneration, protein pathology and neuroinflammation.
Alzheimer's disease is a devastating neurodegenerative disorder characterized by the accumulation of tau tangles and amyloid beta (Aβ) plaques in the brain.
Shares of Athira have rallied 39.5% in the year so far against the industry’s decline of 7.1%.
Image Source: Zacks Investment Research
Top-line data from the LIFT-AD study is now expected by the end of the third quarter of 2024.
The company plans to present full data from the LIFT-AD study at the Clinical Trials on Alzheimer’s Disease conference, which is scheduled to take place later in the year.
Notably, eligible patients from the LIFT-AD study and the phase II ACT-AD study will enroll in the open-label extension study, which can provide insights into the long-term safety and long-term effects of fosgonimeton.
Fosgonimeton, a potentially first-in-class, small molecule drug candidate, is designed to modulate the neurotrophic hepatocyte growth factor system to protect and maintain neuronal health and function.
Apart from AD, fosgonimeton is also being evaluated in the phase II SHAPE study for the potential treatment of Parkinson's disease, dementia and dementia with Lewy bodies.
In the absence of a marketed product, the successful development of fosgonimeton, along with other pipeline candidates, remains in key focus for Athira.
In the past 60 days, estimates for Acrivon Therapeutics’ 2024 loss per share have narrowed from $3.05 to $2.47. Loss per share estimates for 2025 have narrowed from $3.04 to $2.55. Year to date, ACRV shares have rallied 44.9%.
ACRV’s earnings beat estimates in three of the trailing four quarters and missed the same on the remaining occasion, the average surprise being 3.56%.
In the past 60 days, estimates for Adaptive Biotechnologies’ 2024 loss per share have narrowed from $1.30 to $1.29, while loss per share estimates for 2025 have narrowed from $1.09 to $1.02. Year to date, ADPT shares have declined 27.7%.
ADPT’s earnings beat estimates in two of the trailing four quarters, meeting the same once and missing on the remaining occasion, the average surprise being 0.65%.
In the past 60 days, estimates for RAPT Therapeutics’ 2024 loss per share have narrowed from $3.03 to $2.93. Loss per share estimates for 2025 have narrowed from $2.08 to $2.05. Year to date, RAPT shares have declined 87.1%.
RAPT’s earnings beat estimates in two of the trailing four quarters while missing the same on the remaining two occasions, the average surprise being 3.19%.
See More Zacks Research for These Tickers
Normally $25 each - click below to receive one report FREE:
Image: Bigstock
Athira (ATHA) Completes Dosing in Alzheimer's Study, Stock Up
Athira Pharma, Inc (ATHA - Free Report) recently announced that it has dosed the last patient in the phase II/III LIFT-AD study, which is evaluating its pipeline candidate, fosgonimeton for the treatment of mild-to-moderate Alzheimer’s disease (AD). Shares of the company were up 29.4%, following the announcement of the news.
The LIFT-AD study evaluates once-daily fosgonimeton (40 mg) subcutaneous injection versus placebo over a treatment period of 26 weeks in mild-to-moderate AD patients. The study is designed to assess the treatment effects of fosgonimeton across multiple aspects of AD.
The primary endpoint of the LIFT-AD study is to see the change from baseline following 26 weeks of treatment using the Global Statistical Test, which evaluates cognition and function, the two key measures of disease progression.
Other secondary and exploratory endpoints are changes in plasma biomarkers of neurodegeneration, protein pathology and neuroinflammation.
Alzheimer's disease is a devastating neurodegenerative disorder characterized by the accumulation of tau tangles and amyloid beta (Aβ) plaques in the brain.
Shares of Athira have rallied 39.5% in the year so far against the industry’s decline of 7.1%.
Image Source: Zacks Investment Research
Top-line data from the LIFT-AD study is now expected by the end of the third quarter of 2024.
The company plans to present full data from the LIFT-AD study at the Clinical Trials on Alzheimer’s Disease conference, which is scheduled to take place later in the year.
Notably, eligible patients from the LIFT-AD study and the phase II ACT-AD study will enroll in the open-label extension study, which can provide insights into the long-term safety and long-term effects of fosgonimeton.
Fosgonimeton, a potentially first-in-class, small molecule drug candidate, is designed to modulate the neurotrophic hepatocyte growth factor system to protect and maintain neuronal health and function.
Apart from AD, fosgonimeton is also being evaluated in the phase II SHAPE study for the potential treatment of Parkinson's disease, dementia and dementia with Lewy bodies.
In the absence of a marketed product, the successful development of fosgonimeton, along with other pipeline candidates, remains in key focus for Athira.
Zacks Rank & Stocks to Consider
Athira currently carries a Zacks Rank #3 (Hold).
Some better-ranked stocks in the healthcare sector are Acrivon Therapeutics, Inc. (ACRV - Free Report) , Adaptive Biotechnologies Corporation (ADPT - Free Report) and RAPT Therapeutics, Inc. (RAPT - Free Report) , each holding a Zacks Rank #2 (Buy) at present. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.
In the past 60 days, estimates for Acrivon Therapeutics’ 2024 loss per share have narrowed from $3.05 to $2.47. Loss per share estimates for 2025 have narrowed from $3.04 to $2.55. Year to date, ACRV shares have rallied 44.9%.
ACRV’s earnings beat estimates in three of the trailing four quarters and missed the same on the remaining occasion, the average surprise being 3.56%.
In the past 60 days, estimates for Adaptive Biotechnologies’ 2024 loss per share have narrowed from $1.30 to $1.29, while loss per share estimates for 2025 have narrowed from $1.09 to $1.02. Year to date, ADPT shares have declined 27.7%.
ADPT’s earnings beat estimates in two of the trailing four quarters, meeting the same once and missing on the remaining occasion, the average surprise being 0.65%.
In the past 60 days, estimates for RAPT Therapeutics’ 2024 loss per share have narrowed from $3.03 to $2.93. Loss per share estimates for 2025 have narrowed from $2.08 to $2.05. Year to date, RAPT shares have declined 87.1%.
RAPT’s earnings beat estimates in two of the trailing four quarters while missing the same on the remaining two occasions, the average surprise being 3.19%.