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Biogen (BIIB) Q2 Earnings: Taking a Look at Key Metrics Versus Estimates

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Biogen Inc. (BIIB - Free Report) reported $2.65 billion in revenue for the quarter ended June 2025, representing a year-over-year increase of 7.3%. EPS of $5.47 for the same period compares to $5.28 a year ago.

The reported revenue represents a surprise of +13.89% over the Zacks Consensus Estimate of $2.32 billion. With the consensus EPS estimate being $3.93, the EPS surprise was +39.19%.

While investors closely watch year-over-year changes in headline numbers -- revenue and earnings -- and how they compare to Wall Street expectations to determine their next course of action, some key metrics always provide a better insight into a company's underlying performance.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Biogen performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenue- Product- Rare Disease- SKYCLARYS - United States: $78 million compared to the $75.44 million average estimate based on 23 analysts.
  • Revenue- Product- Multiple Sclerosis (MS)- TYSABRI- Rest of world: $182.4 million versus the 23-analyst average estimate of $171.91 million. The reported number represents a year-over-year change of -14.6%.
  • Revenue- Product- Rare Disease- SKYCLARYS - Rest of World: $52.3 million versus $53.63 million estimated by 23 analysts on average.
  • Revenue- Product- Multiple Sclerosis (MS)- TYSABRI- United States: $272.2 million versus $203.91 million estimated by 23 analysts on average. Compared to the year-ago quarter, this number represents a +9.5% change.
  • Revenue- Product- Multiple Sclerosis (MS)- TYSABRI- Total: $454.6 million versus $372.66 million estimated by 27 analysts on average. Compared to the year-ago quarter, this number represents a -1.6% change.
  • Revenue- Product- Rare Disease- SPINRAZA- Total: $392.7 million versus $396.92 million estimated by 27 analysts on average. Compared to the year-ago quarter, this number represents a -8.5% change.
  • Revenue- Product- Rare Disease- SKYCLARYS- Total: $130.3 million versus the 26-analyst average estimate of $128.37 million. The reported number represents a year-over-year change of +30.3%.
  • Revenue- Product, net: $1.88 billion compared to the $1.72 billion average estimate based on 26 analysts. The reported number represents a change of -1.1% year over year.
  • Revenue- Anti-CD20 therapeutic programs: $467.3 million compared to the $431.19 million average estimate based on 26 analysts. The reported number represents a change of +5.1% year over year.
  • Revenue- Product- Multiple Sclerosis (MS)- Fumarate- VUMERITY- Total: $212.3 million versus the 25-analyst average estimate of $170.04 million. The reported number represents a year-over-year change of +28.1%.
  • Revenue- Product- Multiple Sclerosis (MS)- Fumarate- TECFIDERA- Total: $193.6 million versus $178.41 million estimated by 25 analysts on average. Compared to the year-ago quarter, this number represents a -23.2% change.
  • Revenue- Product- Other- ZURZUVAE- Total: $46.4 million versus $32.61 million estimated by 24 analysts on average.

View all Key Company Metrics for Biogen here>>>

Shares of Biogen have returned -4.9% over the past month versus the Zacks S&P 500 composite's +2.7% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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