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Apellis Pharmaceuticals (APLS) Q3 Earnings: How Key Metrics Compare to Wall Street Estimates

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Apellis Pharmaceuticals, Inc. (APLS - Free Report) reported $458.58 million in revenue for the quarter ended September 2025, representing a year-over-year increase of 133%. EPS of $1.67 for the same period compares to -$0.46 a year ago.

The reported revenue represents a surprise of +25.22% over the Zacks Consensus Estimate of $366.21 million. With the consensus EPS estimate being $1.03, the EPS surprise was +62.14%.

While investors closely watch year-over-year changes in headline numbers -- revenue and earnings -- and how they compare to Wall Street expectations to determine their next course of action, some key metrics always provide a better insight into a company's underlying performance.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Apellis Pharmaceuticals performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenue- Product revenue, net: $177.76 million versus the nine-analyst average estimate of $178.43 million. The reported number represents a year-over-year change of +0.7%.
  • Revenue- Licensing and other revenue: $280.82 million versus $126.67 million estimated by nine analysts on average. Compared to the year-ago quarter, this number represents a +1286.2% change.
  • Product Revenue- EMPAVELI: $26.83 million compared to the $22.06 million average estimate based on seven analysts. The reported number represents a change of +9% year over year.
  • Product Revenue- SYFOVRE: $150.93 million compared to the $156.55 million average estimate based on seven analysts. The reported number represents a change of -0.7% year over year.

View all Key Company Metrics for Apellis Pharmaceuticals here>>>

Shares of Apellis Pharmaceuticals have returned +30.1% over the past month versus the Zacks S&P 500 composite's +3.6% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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