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Compared to Estimates, Alnylam (ALNY) Q3 Earnings: A Look at Key Metrics

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Alnylam Pharmaceuticals (ALNY - Free Report) reported $1.25 billion in revenue for the quarter ended September 2025, representing a year-over-year increase of 149.4%. EPS of $2.90 for the same period compares to -$0.50 a year ago.

The reported revenue represents a surprise of +22.25% over the Zacks Consensus Estimate of $1.02 billion. With the consensus EPS estimate being $1.67, the EPS surprise was +73.65%.

While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall Street expectations to determine their next move, some key metrics always offer a more accurate picture of a company's financial health.

As these metrics influence top- and bottom-line performance, comparing them to the year-ago numbers and what analysts estimated helps investors project a stock's price performance more accurately.

Here is how Alnylam performed in the just reported quarter in terms of the metrics most widely monitored and projected by Wall Street analysts:
  • Revenues- Product revenues, net: $851.08 million versus the nine-analyst average estimate of $803.35 million. The reported number represents a year-over-year change of +102.6%.
  • Revenues- Royalty revenue: $46.2 million versus $46.52 million estimated by seven analysts on average. Compared to the year-ago quarter, this number represents a +97.6% change.
  • Net Product Revenue- Oxlumo: $52.83 million compared to the $50.45 million average estimate based on seven analysts. The reported number represents a change of +31.4% year over year.
  • Net Product Revenue- Givlaari: $73.87 million compared to the $79.51 million average estimate based on seven analysts. The reported number represents a change of +4% year over year.
  • Net Product Revenue- Onpattro: $39.08 million compared to the $47.48 million average estimate based on six analysts. The reported number represents a change of -22.3% year over year.
  • Net Product Revenue- Amvuttra: $685.3 million versus $637.51 million estimated by six analysts on average. Compared to the year-ago quarter, this number represents a +165% change.

View all Key Company Metrics for Alnylam here>>>

Shares of Alnylam have returned +4.6% over the past month versus the Zacks S&P 500 composite's +3.6% change. The stock currently has a Zacks Rank #3 (Hold), indicating that it could perform in line with the broader market in the near term.

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