Back to top

Analyst Blog

Avanir Pharmaceuticals, Inc. (AVNR - Snapshot Report) reported that results from a pharmacokinetic (PK) study of AVP-825 were published in the journal, Headache. AVP-825 is being developed using OptiNose's novel Breath Powered intranasal delivery system, which includes low dosages of GlaxoSmithKline plc’s (GSK - Analyst Report) Imitrex (sumatriptan) for the treatment of acute migraine.

The randomized, pharmacokinetic study evaluated the pharmacokinetics of AVP-825 and compared it with the pharmacokinetics of three other sumatriptan products: 20 mg liquid nasal spray, 100 mg oral tablet and 6 mg subcutaneous injection.

Data showed that AVP-825 is highly efficient for delivering sumatriptan with a higher peak exposure (27%), and greater early exposure (75%) in the crucial first 15 minutes after treatment than liquid nasal spray, despite the AVP-825 dose being lower (16 mg). The study also revealed that AVP-825 gave greater overall intranasal delivery efficiency, with the average total drug exposure per milligram being one third higher than the total exposure per milligram achieved with the liquid nasal spray.

Overall, AVP-825 has advantages over other sumatriptan products currently available to treat migraine as it produces rapid and efficient medication absorption.

As per the Centers for Disease Control and Prevention, more than 37 million Americans suffer from migraine headaches.

In Jul 2013, Avanir joined forces with OptiNose for the development and commercialization of AVP-825 for the treatment of acute migraine. Once approved, it will be the first and only fast-acting, dry-powder nasal delivery form of Imitrex.

Avanir currently carries a Zacks Rank #3 (Hold). Companies that look well-positioned include Questcor Pharmaceuticals Inc. (QCOR - Analyst Report) and Actelion Ltd. (ALIOF), both ofwhich carry a Zacks Rank #1 (Strong Buy).

Please login to or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research


Are you a new Zacks Member or a visitor to

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
RPC INC RES 24.91 +8.35%
LITHIA MOTO… LAD 94.59 +4.60%
DELTA AIR L… DAL 39.15 +3.90%
FLAMEL TECH… FLML 14.51 +3.50%
SOUTHWEST A… LUV 28.87 +2.92%