Back to top

Analyst Blog

Alnylam Pharmaceuticals Inc. (ALNY - Analyst Report) recently entered into an exclusive global alliance with The Medicines Company (MDCO - Analyst Report) for the development and commercialization of the prior’s ALN-PCS ribo nucleic acid interference (RNAi) therapeutic program.

Currently under development for the treatment of hypercholesterolemia, ALN-PCS RNAi is an important program in Alnylam’s “Alnylam 5x15” strategy.

As per the terms of the collaboration agreement, The Medicines Company will be making an upfront cash payment of $25 million to Alnylam. Alnylam is also eligible to receive up to $180 million on the achievement of development and commercial milestones. The company could also receive scaled double-digit royalties from The Medicines Company on global products sales of the ALN-PCS products commercialized under this agreement.

The collaboration includes ALN-PCS02 and ALN-PCSsc. ALN-PCS02 is an intravenous RNAi therapeutic which completed a phase I trial, whereas ALN-PCSsc, a subcutaneously administered RNAi therapeutic, is currently in pre-clinical development.

Meanwhile, Alnylam is expected to continue with its ALN-PCS program for another one to two years to complete certain pre-clinical and phase I studies. The Medicines Company will be responsible for the development of the candidates from phase II onwards. The Medicines Company will also be responsible for the commercialization of the candidates if the ALN-PCS program is successful.

Earlier this year, Alnylam had provided a brief update on its key “Alnylam 5x15” pipeline, which aims to develop RNAi therapeutic candidates and partner programs for the next couple of years. The company is expecting several study results based on its RNAi therapeutic candidates in the next two years.

We believe that the company is progressing well with its “Alnylam 5x15” pipeline. We expect investor focus to stay on the successful development of the pipeline, though most of them are in early stages of development.

Alnylam carries a Zacks Rank #4 (Sell). However, other biopharmaceutical stocks such as Targacept Inc. (TRGT - Snapshot Report) and Medivation Inc. (MDVN - Analyst Report) carry a Zacks Rank #1 (Strong Buy) and Zacks Rank #2 (Buy) respectively.

Please login to Zacks.com or register to post a comment.

New to Zacks?

Start Here

Zacks Investment Research

Close

Are you a new Zacks Member or a visitor to Zacks.com?

Top Zacks Features

My Portfolio Tracker

Is it Time to Sell?

One of the most important steps you can take today is to set up your portfolio tracker on Zacks.com. Once you do, you'll be notified of major events affecting your stocks and/or funds with daily email alerts.

More Zacks Resources

Zacks Rank Home - Evaluate your stocks and use the Zacks Rank to eliminate the losers and keep the winners.

Mutual Fund Rank Home - Evaluate your funds with the Mutual Fund Rank for both your personal and retirement funds.

Stock/Mutual Fund Screening - Find better stocks and mutual funds. The ones most likely to beat the market and provide a positive return.

My Portfolio - Track your Portfolio and find out where your stocks/mutual funds stack up with the Zacks Rank.

Zacks #1 Rank Top Movers for Zacks #1 Rank Top Movers

Company Symbol Price %Chg
SYNAPTICS I… SYNA 78.11 +8.14%
CENTURY ALU… CENX 19.88 +5.74%
GREEN PLAIN… GPRE 39.41 +5.12%
PILGRIM'S P… PPC 28.82 +3.08%
THE PANTRY… PTRY 18.41 +2.79%